rhTGF-β_1对异常应力下兔颈椎间盘组织中蛋白多糖的影响  

Effects of rhTGF-β1 on Proteoglycan Content in Cervical Disc of Rabbits under Abnormal Stress

作　　者：夏数数[1] 丁明桥 徐金容 熊勇[4] 邹季[4] 

机构地区：[1]湖北大学校医院骨科,武汉430062 [2]武汉市第五医院 [3]武汉市武昌医院 [4]湖北中医学院

出　　处：《中国中医骨伤科杂志》2009年第2期14-15,共2页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：湖北省自然科学基金项目(2007ABA233)

摘　　要：目的:探讨外源性重组人转化生长因子-β1(recombinant human transforming growth factor-β1,rhTGF-β1)对异常应力环境下兔椎间盘组织蛋白多糖(PG)的影响,寻找预防和延缓椎间盘退变的方法。方法:将24只日本大耳兔随机分为正常组、模型治疗组和模型组。按要求处理8周后,测出颈椎间盘C5/6组织蛋白多糖主要组成糖氨多糖(glycosaminoglycan,GAG)的量。结果:正常组、模型治疗组中GAG含量明显高于模型组(P<0.05);而正常组与模型治疗组之间差异无统计学意义(P>0.05)。结论:椎间盘组织退变的早期,rhTGF-β1可以抑制颈椎间盘(intervertebral disc,IVD)组织GAG的含量降低,从而起到预防和延缓椎间盘退变的作用。Objective：To investigate the effect of recombinant human transforming growth factor--β1 （rhTC-F-β1） on proteoglycan content in cervical disc tissue under abnormal stress so as to probe the method of preventing and retarding the degeneration of cervical disc in rabbits. Methods： Twenty--four Japanese rabbits were randomly divided into control group, treatment group and model group. Eight weeks after treatment, glycosaminoglyean （GAG） in C5/6 disc tissue was measured. Results：GAG in control group and treatment group were significantly higher than that of model group （P〈0.05）, while there was no significant difference between control group and treatment group （P〉0.05）. Conclusion：In the early stage of cervical disc degeneration, rhTGF-β1 might prevent and retard disc degeneration by inhibiting the decrease of GAG content in cervical disc.

关 键 词：椎间盘 退变 RHTGF-Β1 蛋白多糖 

分 类 号：R681.55[医药卫生—骨科学]