一种新型肠传性病毒性肝炎的流行病学、临床、病理和病毒学的初步研究  

An outbreak of enteric transmitted non-A,non-E viral hepatitis: some of epidemiologic,clinical, histologic and virologic features

作　　者：骆抗先[1] 章廉[1] 王珊珊 聂军[1] 葛娅[3] 陈志英 俞守义 刘银燕 杨守昌[1] 梁蔚芳[1] 何海棠[1] 焦成松[3] 

机构地区：[1]第一军医大学南方医院感染内科,广州510515 [2]广州军区医学研究所,广州510000 [3]广州军区武汉总医院,武汉市410000 [4]武汉某职业学校门诊部,武汉410000

出　　处：《第一军医大学学报》1998年第2期87-90,共4页Journal of First Military Medical University

基　　金：军队"九五"重点课题!98Z073

摘　　要：背景单项血清肝酶增高的病因长期不明，某校学生中发生381例以此为主要特征的肝损害病人。目的为初步阐明这一疾病的病因、传播和病变。方法流行病学调查、临床观察、肝活组织检查以及血清和粪便的聚合酯链反应检测。结果根据临床和检测结果可排除中毒引起，已知肝炎病毒的血清标志物均明性。症状轻微，病程多急性、少数可超过6个月。肝组织呈汇管区炎。散在发病后进行3次人群普查，3个月累计发病率占流行人群的60．7％。分析认为经日常生活接触和多次小范围的食物传播。采取以切断传播为主的预防措施，2个月后流行控制。由病人的急性期血清和潜伏期粪便提取DNA，检出与一种新近报告的血传性病毒（TTV）有同源性的基因片段。结论可能是另一种肠传型肝炎病毒引起的非甲非戊型病毒性肝炎。Objective The cause of isolated serum transaminase elevation has not been clear yet. An outbreak of the disorder occurred in hundreds of students at a technician school. To define the disorder and eliminate the etiology. Methods Epidemio logical investigation,clinical observation,liver biopsy and virology study. Results The major feature was transaminase elevat ed,but all serum markers of known hepatitis were negative. The symptoms were mild and self- limited,whereas a few patients had a prolonged and relapsed course. Histology revealed mild portal hepatitis or only reactive inflammation. The disease has al ready appeared from 1994, and outbreak formed after October 1996. Totally, 381 cases occurred and the case rate was as high as 60. 7%. The daily-life contact and small scale food transmission were considered. The epidemic was controlled 2 month later since prevention measures for gastroenteric infection had been carried out. Couclusions The disorder might be non-A,nonE,another type of enteric transmitted viral hepatitis.

关 键 词：病毒性肝炎 胃肠道传播 流行病学 病理学 

分 类 号：R512.6[医药卫生—内科学]