雌激素替代疗法对绝经后妇女血浆一氧化氮的影响  

The Effect of Estrogen Replacement Therapy on Plasma Nitric Oxide Levels in Postmenopausal Women

作　　者：叶元华[1] 戴淑真[1] 张少静[1] 

机构地区：[1]青岛医学院附属医院妇产科

出　　处：《中华妇产科杂志》1998年第6期340-341,共2页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的探讨雌激素替代疗法（ＥＲＴ）对绝经后妇女血浆一氧化氮（ＮＯ）含量的影响。方法测定１７例健康绝经后妇女（健康组），２１例患高血脂症绝经后妇女（高血脂组）应用ＥＲＴ前及应用ＥＲＴ４周后血浆ＮＯ及血清雌二醇（Ｅ２）含量，并与１０例健康绝经后妇女应用安慰剂（对照组）进行对照。结果对照组应用安慰剂前后，ＮＯ含量无变化；健康组及高血脂组应用ＥＲＴ后，ＮＯ含量明显升高，健康组升高尤其明显；健康组应用ＥＲＴ４周后Ｅ２水平与ＮＯ升高有明显相关性。结论绝经后妇女补充雌激素，可通过升高ＮＯ含量发挥其对心血管的保护作用。Objective To investigate the effect of estrogen replacement therapy (ERT) on plasma nitric oxide (NO) levels in postmenopausal women (PMW). Methods The plasma concentrations of NO and serum concentrations of estradiol (E 2) were assessed before and 4 weeks after placebo or ERT administration in 10 cases of healthy PMW (control group), 17 cases of healthy PMW (healthy group) and 21 cases of PMW with hyperlipidemia (hyperlipidemia group) respectively. Results There was no difference in NO concentrations between before and after placebo administration in control group. In healthy and hyperlipidemia groups, the mean concentrations of NO were significantly higher 4 weeks after ERT administration than baseline. The positive correlation between the mean percent increase of NO and the E 2 concentrations after ERT administration was statistically significant in healthy group. Conclusion The increase of plasma NO concentrations caused by ERT may contribute to it cardiovascular protective effect in PMW.

关 键 词：雌激素替代疗法 一氧化氮 绝经后期 

分 类 号：R588.05[医药卫生—内分泌]