氯仿对大鼠皮肤屏障功能的影响  

EFFECTS OF CHLOROFORM ON SKIN BARRIER FUNCTION

作　　者：王旭平[1] 任道凤[1] 金锡鹏[1] 

机构地区：[1]上海医科大学公共卫生学院劳动卫生教研室

出　　处：《上海医科大学学报》1998年第3期213-214,共2页Journal of Fudan University(Medical Science)

基　　金：国家自然科学基金

摘　　要：目的研究氯仿对大鼠皮肤屏障功能的影响。方法对３天龄ＳＤ大鼠的活体皮肤进行氯仿涂搽、接触１０和２０ｍｉｎ的处理，采用静式渗透模型，以氚水经皮渗透量作为皮肤屏障功能的评价指标。结果３个氯仿接触组的氚水经皮渗透量均随时间递增，高于对照组，并在一定时点具有统计学意义（Ｐ＜０．０５），且３个氯仿接触组的氚水经皮渗透量的大小顺序为氯仿接触２０ｍｉｎ＞接触１０ｍｉｎ＞涂搽。结论经氯仿处理后皮肤的屏障功能降低，与皮肤接触氯仿的水平相关。URPOSE To investigate effects of chloroform on skin barrier function of rat.METHODS An in vitro skin model of threedayold rat skin was used. The tritium water penetration amount through skin was applied as an index of evaluating skin barrier function.RESULTS Tritium water penetration amount through skin treated by chloroform were increased with time, and significantly higher than the control at some times (P<0.05). The order of tritium water penetration amount through skin treated by chloroform among three exposed group was contact 20min group >contact 10min group>scrub group.CONCLUSIONS Skin barrier function decreased after exposed to chloroform,and related with the exposed level of chloroform.

关 键 词：氯仿 皮肤屏障功能 大鼠 

分 类 号：R136.32[医药卫生—劳动卫生]