乙型肝炎病毒基因型和早期病毒学应答对干扰素-α2b治疗慢性乙型肝炎疗效的预测价值  

Effect of hepatitis B virus genotypes and rapid virological reponse to interferon-α2b on the efficacy of patients with chronic hepatitis B receiving interferon therapy

作　　者：肖扬 周岳进 郑金莉 胡操寒 胡侠 卢成鸿 张文静 潘华将 

机构地区：[1]解放军第118医院肝病科,浙江省温州市325000

出　　处：《实用肝脏病杂志》2009年第1期23-24,80,共3页Journal of Practical Hepatology

摘　　要：目的观察乙型肝炎病毒基因型以及早期HBV DNA应答对干扰素-α2b疗效的影响。方法136例慢性乙型肝炎患者接受干扰素-α2b治疗6个月,观察治疗结束时患者乙型肝炎病毒血清标志物、HBV DNA和ALT的变化。结果在完成治疗的129例患者中,C型感染者57例,B型感染者42例,B/C感染者30例。在治疗结束时,B型患者的综合应答率为42%,优于C型28%及B/C混合型16%。多变量Logistic回归分析显示,治疗3月时HBV DNA呈现应答者,治疗结束时应答率高(HBV DNA快速应答的偏回归系数=0.801,P=0.001,优势比=4.5,优势比的95%可信区间为3.01～5.28)。结论快速病毒学应答和感染病毒的基因型可以预测干扰素-α2b治疗慢性乙型肝炎的疗效。Objective To investgate the effect of hepatitis B virus genotypes and rapid virological reponse to interferon-α2b on the efficacy of patients with HBeAg positive chronic hepatitis B at the end of interferon therapy. Methods HBV genotypes were assayed by polymerase chain reaction and the amplified products were detected by Caliper-1000 microcurrent chip. 129 patients received interferon-α2b treatment for 6 months. All subjects were assessed for loss of HBeAg,presence of anti-HBe,HBV DNA loss,and normalization of serum alanine aminotransaminase. Results At the end of treatment,the combined complete response rate in patients with HBV genotype B infection was 42% ,while in patients with HBV genotype C and B/C infection were 28% and 16.7%（P〉0.05）. Rapid virological response to interferon- α2b therapy also prodicted a good anti-viral efficacy at the end of the regimen. Conclusion Rapid virological response to interferon-α2b and the HBV genotypes may influence the response of patients with chronic hepatitis B to interferon therapy.

关 键 词：乙型肝炎 基因型 干扰素-Α2B 病毒学应答 

分 类 号：R512.62[医药卫生—内科学]