甘寒归肝肾经中药药性研究(Ⅰ)--对免疫功能低下小鼠免疫功能的影响  

Study on Chinese herbs property about sweet,cold and channel tropism of liver and kidney(SC-LK)(1):immune function effect on immunosuppressive mice

作　　者：张霄翔[1] 王艳苹[1] 王玉凤[2] 陈少兵[1] 

机构地区：[1]合肥工业大学化工学院,合肥230009 [2]安徽中医学院,合肥230038

出　　处：《中华中医药杂志》2009年第2期240-242,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：安徽省教育厅青年教师“资助计划”项目(No.2004jq171)

摘　　要：目的:探讨甘寒归肝肾经中药药性与免疫增强药理活性之间的关系,寻找归肝肾经甘寒中药有别于其他中药的共同药效。方法:以环磷酰胺(cyclophosphamide,CTX)制备小鼠免疫低下模型并结合体外药理实验,测定灌胃给药后小鼠体内巨噬细胞吞噬率、体外腹腔巨噬细胞(macrophage,Mф)活性及其吞噬鸡红细胞(chicken red blood cell,CRBC)的功能、血清溶血素抗体水平,并观察植物血凝素(phytohemagglutinin,PHA)诱导T淋巴细胞的增殖反应。结果:甘寒归肝肾经中药显著提高免疫抑制小鼠的免疫功能。结论:提高免疫抑制小鼠的免疫功能是甘寒归肝肾经中药药效谱(药性)中的一项共同药效,但与另3类中药比较,不具备特有性。Objective： To study effect of SC-LK on the immune function of immunosuppressive mice and to seek the relationship between drug property of SC-GS and immunoenhancement activity. Methods： The immunosuppressive mice models were established by CTX and administrated with four groups of drugs. The phagocytic ability of macrophage, serum hemolysin level, and proliferative response of T lymphocyte induced by PHA were measured. The activity of in vitro M Ф and the phagocytizing of CRBC by M dp were measured, Results： SC-LK could significantly improve immunological function inhibited by CTX in mice. Conclusion： The improving of immunological function was a common effect in drug effect spectrum （drug property） of SC-LK, but it was not characteristic effect as compared with the other three groups of drugs.

关 键 词：中药药性 药效谱 免疫功能 

分 类 号：R285[医药卫生—中药学]