加减地黄饮子对糖尿病大鼠海马CA1区神经元c-fos表达的影响  

Effect of modified Dihuang decoction on expression of c-fos positive neuronin in hippocampal CA1 area in diabetic rats

作　　者：魏艳菊 张跃明[2] 

机构地区：[1]武钢总医院,武汉430080 [2]浙江中医药大学,杭州310053

出　　处：《中华中医药杂志》2009年第2期243-245,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：浙江省中医药科技计划项目(No.2006C003)

摘　　要：目的:观察加减地黄饮子对糖尿病大鼠海马CA1区神经元c-fos表达的影响。方法:腹腔内注射链脲佐菌素(STZ)制作糖尿病大鼠模型,于造模4周后以免疫组化法观察加减地黄饮子对糖尿病大鼠海马CA1区神经元c-fos表达的影响。结果:加减地黄饮子防治组大鼠海马CA1区神经元c-fos阳性细胞密度和平均光密度(8.13±1.70,0.46±0.08)较糖尿病组(9.25±2.36,0.56±0.06)均降低(P<0.05)。结论:加减地黄饮子可以有效防治糖尿病大鼠海马神经元退行性变化。Objective： To investigate the effect of modified Dihuang decoction on expression of c-los positive neuron in hippocampal CA1 area in diabetic rats. Methods： The diabetic rat models were induced by intraperitoneal injection of streptozotocin （STZ）. 4 weeks later, the expression of c-los was detected by immuno-histocbemistry. Results： Compared with diabetes group （ 9.25±2.36, 0.56 ±0.06 ） , the positive cell＇s density and average light density （ 8.13±1.70, 0.46±0.08 ） of c-fos positive neuron in hippocampal CA1 area in diabetic rats which were prevented and treated with modified Dihuang decoction both decreased（P〈0.05）. Conclusions： Modified Dihuang decoction can prevent and treat the degeneration of hippocampus in diabetic rats.

关 键 词：加减地黄饮子 糖尿病 海马 C-FOS 

分 类 号：R285.5[医药卫生—中药学]