十四种治疗肿瘤常用中药元素含量的测定及聚类分析  

Determination and cluster analysis of element contents in fourteen commonly used anti-tumor TCM

作　　者：孙卫民[1] 于昆[1] 薛大方[2] 徐恒瑰[1] 滕文锋[1] 

机构地区：[1]大连医科大学检验医学院,大连116044 [2]辽宁出入境检验检疫局技术中心,大连116000

出　　处：《中华中医药杂志》2009年第2期251-255,共5页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:分析肿瘤治疗常用14种中药的元素含量;研究中药元素含量与中药性味功效的相关性,以期为中药的分类和评价提供一种新的方法。方法:采用微波消解法处理样品,电感耦合等离子体质谱(ICP-MS)法测定14种中药中19种元素的含量,用统计软件(SPSS11.5)进行系统聚类分析。结果:14种中药分成两大类,与中医药传统性味和功效分类相符,相关系数r>0.80时,有2种药物聚类相似;相关系数r>0.70时,有2对药物聚类相似。结论:用元素含量作为中药的特征对中药进行分类方法可行,相关系数较大的药物,其药物性味功效相似性较大,揭示中药中元素含量与药物性味功效密切相关,为定量判断不同中草药间的性味类属关系提出了参考指标。Objective： To determine the contents of elements in 14 kinds of common used anti-tumors TCM, and to investigate the association between the element contents and the flavor, nature and efficacy of these medicine, and to develop a new method to classify and evaluate the quality of TCM. Methods： The fourteen samples were treated by microwave digestion, and the contents of elements were determined by ICP-MS. The data from nineteen elements were cluster analyzed with SPSS 11.5 software package. Results： 14 kinds of TCM were sorted into two categories, which matched the cluster divided by the nature and flavor of TCM. When correlation coefficient（r） was exceeded 0.80, cluster in two kinds of medicines are similar, when r 〉 0.70, cluster in two pairs of medicines are similar. Conclusion： It＇s reliable to cluster analysis the TCM by regarding the element contents as the character of these medicines. The larger the correlation coefficient is, the more similar the nature, flavor and efficacy of the medicines are, which suggested that trace element contents were closely related to （have much to do with） the flavor, nature and efficacy. The study provides method for the cluster relationship among TCM.

关 键 词：元素 中药 聚类分析 电感耦合等离子体质谱(ICP-MS) 

分 类 号：R287[医药卫生—中药学]