辛伐他汀治疗后糖化血红蛋白对血脂的影响  

EFFECT OF BLOOD HBA1C ON LIPIDEMIA IN PATIENTS WITH TYPE 2 DIABETES TREATED WITH SIMVASTATINE

作　　者：卓胜青[1] 杨雪苹[1] 陈勇驰[1] 杨辉剑[1] 连环[1] 龚彩平[1] 

机构地区：[1]广东省人民医院广东省老年医学研究所,广东广州510080

出　　处：《现代医院》2009年第1期27-28,共2页Modern Hospitals

摘　　要：目的探讨2型糖尿病患者用辛伐他汀降脂治疗后血糖控制状况对血脂的影响。方法对93例住院的已行辛伐他汀降血脂治疗的2型糖尿病患者的糖化血红蛋白(HbA1c)、血脂进行分析,将病人分为HbA1c升高组和HbA1c正常组,观察HbA1c浓度对血脂的影响。结果辛伐他汀降血脂治疗后2型糖尿病患者HbA1c升高组的TRIG较高,HDLC和APOA较低,且均有显著性差异(p<0.05),而CHOL、LDLC和APOB在两组间无显著性差异。结论2型糖尿病患者经辛伐他汀降血脂治疗后,血糖水平对的血脂影响仍然存在,因此降脂治疗的同时应注意血糖对血脂的影响。Objective To investigate lipidemia disorder and effect of glucose on lipidemia in patients with type 2 diabetes （T2DM） treated with Statin. Methods 93 patients with T2DM were enrolled and the levels of blood lipid （ TRIG, CHOL, HDLC, LDLC, APOA, APOB ）, HbAlc were measured. Results HbAlc was correlated with TRIG positively （p 〈 0.05 ） ; and correlated with HDLC and APOA negatively （p 〈0. 05 ）. And there were no significant difference of CHOL, LDLC and APOB between the two groups. Conclusion In patients with T2DM treated with Statin the influence of blood glucose on lipid is existing. The levels of glucose and lipid should be both controlled to prevent atheroselerosis.

关 键 词：2型糖尿病 糖化血红蛋白 血脂 

分 类 号：R587.1[医药卫生—内分泌] R972.6[医药卫生—内科学]