甘草酸对哮喘小鼠一氧化氮及一氧化氮合酶的影响  

Effect of Glycyrrhizin on Nitric Oxide and Nitric Oxide Synthase in Mice Model of Pronchial Asthma

作　　者：吕小华[1] 吴铁[1] 覃冬云[1] 

机构地区：[1]广东医学院,广东湛江524023

出　　处：《时珍国医国药》2009年第1期40-41,共2页Lishizhen Medicine and Materia Medica Research

基　　金：广东省社会发展领域科技计划项目(No.73044)

摘　　要：目的观察甘草酸对哮喘小鼠血清中一氧化氮(NO)、一氧化氮合酶(NOS)活性的影响,探讨甘草酸防治支气管哮喘的可能机制。方法建立小鼠卵蛋白哮喘模型,测定正常、模型、激素和甘草酸各组血清中NO含量及NOS活性的变化。结果模型组小鼠血清中NO含量及NOS活性的较正常组显著升高(P<0.01),甘草酸组血清中NO及NOS较模型组显著降低(P<0.05)。结论甘草酸可降低哮喘小鼠血清中NO含量及NOS水平,对支气管哮喘有一定的防治作用。Objective To observe the effects of glycyrrhizin on nitric oxide and nitric oxide synthase in a mice model of bronchial asthma and to explore the mechanism of glycyrrhizin for treating asthma. Methods The mice model of bronchial asthma was established. The changes of the content of NO and the activity of NOS in every group were observed in serum. Results The content of NO and the activity NOS in model group were increased as compared with normal group （ P 〈 0.01 ） and markedly decreased in glycyrrhizin group as compared with model group（ P 〈 0.05 ）. Conclusion Glyeyrrhizin can decrease the activity of NO and the content of NOS in serum and exert preventive and therapeutic effect for asthma.

关 键 词：甘草酸 支气管哮喘 一氧化氮 一氧化氮合酶 

分 类 号：R285.5[医药卫生—中药学]