急性冠脉综合征患者血清IL-10和TGF—β的变化及其临床意义  

Clinical significance of changes of serum IL-10 and TGF-β levels in patients with acute coronary syndrome

作　　者：陈丹丹[1] 王敬萍 刘慧荣[3] 

机构地区：[1]山西医科大学2006级,太原市030001 [2]山西省心血管病医院 [3]山西医科大学生理教研室

出　　处：《中国心血管病研究》2009年第2期81-83,共3页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金（30572084）

摘　　要：目的观察急性冠脉综合征（ACS）患者血清白细胞介素-10（IL-10）和转化生长因子-β（TGF-β）水平变化，探讨抗炎性细胞因子对ACS发病的影响。方法受试者分为急性冠脉综合征组（ACS组，30例）、稳定型心绞痛组（SA组，18例）及对照组（NCA组，18例）3组，于清晨空腹取静脉血，采用ELISA方法测定外周血中细胞因子IL-10和TGF-β水平，常规检测血糖及血脂水平。结果ACS组血清IL-10和TGF-β水平[（11．35±2．04）pg／ml，（5．85±2．0）ng／ml]显著低于SA组[（13．03±2．24）pg／ml，（9．37±2．76）ng／ml]和对照组[（14．43±3．52）pg／ml，（11．21±4．7）ng／ml]（P〈0．05），而后两组血清IL-10和TGF—β水平差异无统计学意义（P〉0．05）。结论抗炎性细胞因子IL-10和TGF—β在动脉粥样硬化的发生、发展中起-定的保护性作用。在ACS发生、发展过程中，血清IL—10和TGF—β水平明显降低，并且可能存在着一种动态改变。Objective To measure serum interleukin-10 （IL-10）, transforming growth factor-β （TGF-β） and assess the role of these anti-inflammatory cytokines on the stability of plaques and the development and progression of atherosclerosis. Methods Three group of subjects were enrolled ： group 1, patients with acute coronary syndrome （ACS） （n=30）,group 2, patients with stable angina（SA） （n=18）, group 3, subjects with normal coro- nary artery （NCA） on angiography （n=18）. Blood samples of all subjects were collected on an empty stomach in the morning. The serum concentrations of IL-10 and TGF-β were measured using an ELISA technique. Results The serum concentrations of IL-10 and TGF-β were significantly lower in the ACS group [（11.35±2.04）pg/ml, （5.85＋2.0）ng/ml] compared with the SA group [（13.03±2.24）pg/ml, （9.37±2.76）ng/ml] and the NCA group [ （ 14.43±3.52）pg/ml, （ 11.21±4.7 ）ng/ml]（P〈0.01 ）. It showed no significant difference between the SA group and the NCA group（P〉0.05）. Conclusion As anti-inflammatory cytokines, IL-10 and TGF-β may play a protective role in the development and progression of atheroselerosis. In the development of acute coronary syndrome, the serum level of IL-10 and TGF-β degrade markedly, and it may change dynamically.

关 键 词：冠状动脉疾病 动脉硬化 白细胞介素-10 转化生长因子-Β 

分 类 号：R541.4[医药卫生—心血管疾病]