微乳中界面聚合法制备包载胰岛素纳米胶囊  

Preparation of insulin nanocapsules by interfacial polymerization in microemulsion

作　　者：朱银燕[1] 安学勤[1] 

机构地区：[1]南京师范大学化学与环境科学学院生物功能材料江苏省重点实验室,江苏南京210097

出　　处：《日用化学工业》2009年第1期5-8,共4页China Surfactant Detergent & Cosmetics

基　　金：国家自然科学基金资助项目(20673059);江苏省普通高校自然科学研究计划资助项目(07KJD150099)

摘　　要：通过界面聚合法,以嵌段共聚物表面活性剂作为乳化剂得到结构紧密的微乳液,在该微乳液中制备聚氰基丙烯酸乙酯(PECA)纳米胶囊,产物粒径较小(约100 nm),与作为模板的微乳液液滴大小相对应。微乳组成对纳米胶囊粒径影响较大。微乳聚合所得聚氰基丙烯酸乙酯纳米胶囊对胰岛素的包裹率较大,最大超过90%。同时考察了胰岛素从纳米胶囊中的释放行为。Insulin nanocapsules were prepared by means of interfacial polymerization of poly （ethyl 2 - cyanoacrylate） in microemulsions formed by block copolymer surfactant as emulsifier. Particle size of the nanocapsules achieves a small value around 100 nm that is corresponding to the size of the droplet in the microemulsion, which acts as the templet. Composition of the microemulsion has a big influence on the particle size of the nanocapsules. By means of this method, the extent of encapsulation of the product achieves than 90% or more. The releasing behavior of insulin from the nanocapsules of the product was examined.

关 键 词：纳米胶囊 微乳液 界面聚合 药物控释 

分 类 号：TB383.1[一般工业技术—材料科学与工程]