低硒对大鼠心肌肌浆网Ca转运的影响  

EFFECT OF SELENIUM DEFICIENCY ON Ca TRANSPORT OF MYOCARDIAL SARCOPLASMIC RETICULUM FROM RAT

作　　者：王玉珍[1] 贾锡安[1] 赵君庸[1] 

机构地区：[1]西安生物化学教研室,西安710061

出　　处：《西安医科大学学报》1998年第2期151-154,共4页Journal of Xi'an Medical University(Chinese)

基　　金：国家"七五"攻关资助!75-62-03-03

摘　　要：用克山病病区低硒粮饲料和该饲料补硒喂养大鼠，动态观察了喂养1、2和3个月时两组大鼠心肌肌浆网钙转运功能的改变。结果表明：在各喂养期，低硒组大鼠心肌肌浆网Ca2+－ATPase活性和Ca2+摄取速率均明显低于补硒组，而脂质过氧化物浓度则显著高于同期补硒组。提示低硒大鼠心肌肌浆网Ca2+－ATPase活性和Ca2+摄取下降可能是脂质过氧化增高的结果。Two groups of weanling SpragueDawley rats were fed on a low-selenium basal diet and the same diet supplemented with sodium selenite,respectively,for 1, 2 and 3 months. At each feeding time,the Ca2+ -ATPase activity,Ca2+ uptake rateand the capacity of Ca2+ uptake in isolated cardiacsarcoplasmic reticulum from the Se-deficient ratswere decreased significantly compared to those fromthe Se-supplemented rats; but the content of lipidperoxide in sarcoplasmic reticulum from the Se-deficient rats was significantly higher than that from Sesupplemented rats. The results suggest that the enhancement of lipid peroxidation via Se deficiencymight be responsible for the decreases of Ca2+ -AT-Pase and Ca2+ uptake activities in sarcoplasmic reticulum in Se-deficient animals.

关 键 词：硒 心肌肌浆网 大鼠 钙 脂质过氧化 

分 类 号：R542.202[医药卫生—心血管疾病] R977.9[医药卫生—内科学]