手术联合血浆置换成功治疗副肿瘤性天疱疮1例  

Paraneoplastic pemphigus successfully treated with tumor excision and plasmapheresis as well as corticosteroids

作　　者：钟珊[1] 王兵[1] 黄永初[1] 杨勇[1] 陈喜雪[1] 朱学骏[1] 

机构地区：[1]北京大学第一医院皮肤性病科,北京100034

出　　处：《临床皮肤科杂志》2009年第2期121-123,共3页Journal of Clinical Dermatology

摘　　要：报告手术联合血浆置换成功治疗1例副肿瘤性天疱疮。患者女,16岁。口腔黏膜糜烂3个月,全身出现丘疹及丘疱疹20 d,通过影像学、组织病理及免疫学检查,诊断为副肿瘤性天疱疮。给予患者口服糖皮质激素和血浆置换联合治疗后,行手术切除肿物。术后组织病理检查示Castleman病,透明血管型。于术后再行血浆置换,皮损逐渐好转。治疗过程中免疫学指标逐渐下降。A 16-year-old female presented with severe mucosal erosion and polymorphous cutaneous eruption, diagnosed as paraneoplastic pemphigus with characteristic histopathology and immunologic features. She was treated with tumor excision after the combination treatment with corticosteroids and plasmapheresis, The histopathology of the biopsy specimens showed Castle- man＇s disease, hyaline-vascular type. She received plasmapheresis again after the operation and got improvement which was demonstrated by immunologic monitoring.

关 键 词：天疱疮 副肿瘤性 CASTLEMAN病 血浆置换 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]