骨形态发生蛋白与骨缺损的修复  

Bone morphogenetic protein and bone defect repair

作　　者：曲志强[1] 何慕舜[1] 曾月东[1] 代宇[1] 

机构地区：[1]深圳市龙岗中心医院骨科,广东省深圳市518116

出　　处：《中国组织工程研究与临床康复》2009年第2期345-348,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：骨缺损发生后,骨的生理连续遭严重破坏,在利用外源性骨形态发生蛋白治疗时,必须有适合的载体,通过该载体将外源性骨形态发生蛋白及其它生长因子释放到骨质缺损部位,诱导新骨形成从而达到治疗目的。骨形态发生蛋白的载体材料很多,主要包括无机材料、高分子聚合材料、生物性材料以及这些材料的复合物,但各有不足之处。许多学者对其加以改进,使其更有利于发挥骨形态发生蛋白的诱骨活性。载体或局部基因释放的骨形态发生蛋白可有效修复骨缺损,为治疗骨缺损提供了新途径。Physical continuity of bone is damaged following bone defects. The use of exogenous bone morphogenetic protein （BMP） treatment depends on appropriate carrier, which releases exogenous BMP and other growth factor into the bone defect site inducing new bone formation and achieving therapeutic purposes. There are many carrier materials for BMP, including inorganic material, synthetic polymers, biological material, and composites of these three materials. But all have some deficiencies. So many researchers have optimized them by combined, physical and chemical methods to improve the bone inductive activity. BMP, which is released from carrier or local gene, can repair bone defect effectively, affording a new way for bone defect repairing.

关 键 词：骨形态发生蛋白 骨缺损 基因治疗 

分 类 号：R336[医药卫生—人体生理学]