趋化因子在HBV感染发病中的作用  

Roof of Chemokines in Development and Progression of Hepatitis Virus B

作　　者：靳冠楠(综述)[1] 周玉(审阅)[2] 沈关心(审阅)[2] 

机构地区：[1]华中科技大学同济医学院临床医学八年制,武汉市430030 [2]华中科技大学同济医学院免疫学系,武汉市430030

出　　处：《医学分子生物学杂志》2009年第1期74-77,共4页Journal of Medical Molecular Biology

基　　金：国家重点基础研究发展规划（973计划）（No.2007CB51290）

摘　　要：乙型肝炎是一种以局部炎性为主的感染性疾病，乙型肝炎病毒（HBV）感染宿主细胞后可诱导宿主细胞中趋化因子分泌及其受体表达，趋化因子／受体的相互作用进一步介导中性粒细胞、淋巴细胞等向炎症部位聚集，参与组织损伤；同时诱导T、B细胞分化成熟，对乙型肝炎的发展与转归、肝组织的损伤与修复有重要影响。HBV引发的慢性乙型肝炎（CHB）以Th1细胞性炎性反应为主，研究表明乙型肝炎中某些趋化因子在肝脏高表达，其受体CXCR3和CCR5在Th1细胞高表达。趋化因子尤其是CXC和CC亚家族趋化因子在趋化Th1细胞中发挥重要的作用：Hepatitis B is an infectious disease characterized by regional inflammation. HBV affects expression of chemokines and their receptors in host cell. Interaction between chemokine and receptor further mediates recruitment of neutrophils, lymphocytes and other cells to inflammatory cite to participate in tissue trauma and induce differentiation of T/B lymphoeytes, thereby playing an important role in development and maturation of hepatitis B and in damage and repair of liver tissue. Thl inflammatory cells are predominant during chronic HBV infection. Studies have proven that some chemokines are highly expressed in hepatitis B, while their receptors are highly expressed in Thl cells. In this review, we emphasize that chemokines, particularly their receptors CXC and CC expressed on Thl cells, play important roles in Th1 cells.

关 键 词：趋化因子 乙型肝炎病毒 慢性乙型肝炎 

分 类 号：R392[医药卫生—免疫学] R373.2[医药卫生—基础医学]