2003-2005年医院感染不动杆菌属耐药调查分析  

Antibiotic-resistance of Acinetobacter spp Nosocomial Infection:Analysis from 2003 to 2005

作　　者：黄娟[1] 覃金爱[1] 黄春芳[1] 郭世辉[1] 

机构地区：[1]广西医科大学第一附属医院医院感染管理科,广西南宁530021

出　　处：《中华医院感染学杂志》2009年第1期99-101,共3页Chinese Journal of Nosocomiology

基　　金：广西自然科学基金(桂科自0447052)

摘　　要：目的了解医院感染不动杆菌属细菌对临床常用抗菌药物耐药现状。方法对2003-2005年198例不动杆菌属医院感染病例进行回顾性调查及耐药情况统计。结果不动杆菌属主要来源于痰液(74.75%)和创伤分泌物(11.61%)标本;除哌拉西林/他唑巴坦和美罗培南外,其他药物3年间耐药水平差异无统计学意义;198株不动杆菌属对13种抗菌药物总耐药率为:亚胺培南/西司他丁2.53%、美罗培南2.02%、头孢哌酮/舒巴坦30.81%、哌拉西林/他唑巴坦38.38%、阿米卡星53.54%、头孢吡肟61.11%、左氧氟沙星66.67%、头孢他啶66.16%、环丙沙星68.69%、庆大霉素67.68%、复方新诺明63.64%、哌拉西林70.72%、氨曲南85.35%。结论不动杆菌属细菌对临床常用抗菌药物耐药现象严重,仅亚胺培南/西司他丁和美罗培南保持高度抗菌活性。OBJECTIVE To investigate the drug-resistance rate of strains isolated from nosocomial infection patients with Acinetobacter spp. METHODS A total of 198 patients with Acinetobacter spp nosocomial infection were studied retrospectively from 2003 to 2005. The antibiotic resistance profiles were specifically analyzed. RESULTS The strains of Acinetobacter spp were mainly isolated from sputum （74. 75%） and wound secretion （11. 61%） specimens. There were no significant differences in the resistance of Acinetobacter spp against antibiotics in 3 years except piperaeillin/tazobactam and meropenem. The resistance rate of all 198 strains to 13 kinds of antibiotics were as following： imipenem/cilastatin 2. 53%, meropenem 2. 02%, cefoperazone/sulbactam 30. 81%, piperacillin/ tazobactam 38. 38%, amikacin 53. 54%, cefepime 61. 11%, levofloxacin 66. 67%, ceftazidime 66.16%, ciprofloxacin 68.69%, gentamicin 67.68G, sulfamethoxazole/trimethoprim 63.64%, piperacillin 70.72%, and aztreonam 85. 35%. CONCLUSIONS It is indicated that Acinetobacter spp are highly resistant to the common antibiotics, but still sensitive to imipenem/cilastatin and meropenem.

关 键 词：医院感染 不动杆菌属 抗菌药物 耐药性 

分 类 号：R378[医药卫生—病原生物学]