妊高征患者血浆神经肽的变化及其临床意义  

Changes of some plasma neuropeptides in patients with PIH and their clinical significance.

作　　者：张师前[1] 董艳[1] 韩波[2] 张浩如[3] 

机构地区：[1]山东医科大学附属医院 [2]山东省枣庄市立医院 [3]山东省潍坊市妇幼保健院

出　　处：《中国实用妇科与产科杂志》1998年第1期27-28,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：应用放射免疫法测定３２例中、重度妊高征患者血浆β－内啡肽（β－ＥＰ）、亮啡肽（ＬＥＫ）、精氨酸加压素（ＡＶＰ）、神经降压肽（ＮＴ）质量浓度，并以４４例正常孕妇作比较。结果：妊高征患者β－ＥＰ、ＬＥＫ较正常孕妇明显降低（Ｐ＜０．００１），ＡＶＰ明显升高（Ｐ＜０．０１），ＮＴ无变化；β－ＥＰ与ＡＶＰ呈负相关。产后４８小时，妊高征患者收缩压、舒张压及平均动脉压明显下降，β－ＥＰ、ＬＥＫ明显升高，ＡＶＰ虽有下降，但无统计学差异。提示：β－ＥＰ与ＬＥＫ的变化可能参与了妊高征患者血压升高的发病机制。Objectitve:To evaluate the plasma concentration and their changes of neuropeptides of patients with PIH.Methods:32cases of PIH were enrolled in our study,as well as 44 normotensive pregnant women served as control.Plasma neuropeptides including betaendophin(β-EP),Leucine enkephalin(LEK),argine vasopressin (AVP) and neurotensin(NT)were measured by RIA method.Results:Plasma β-EP and LEK decreased significantly in patients with PIH (P<0.001),plasma AVP in the PIH were significantly elevated compared with that in the control(P<0.01),β-EP and AVP were in negative correlation.48 hours after delivery,SBP,DBP,MAP decreased,while β-EP and LEK increased significantly in PIH patients.AVP decrease showed no significance.Conclusion:β-EP and LEK may be responsible for the hypertension of PIH. \ \

关 键 词：神经肽 妊娠高血压 综合征 血压 

分 类 号：R714.246[医药卫生—妇产科学]