血浆置换术在妊高征治疗中的临床应用(附5例病例报告)  

Clinical application of plasma exchange to the treatment of PIH(With report of 5 cases).

作　　者：成黛丽[1] 李绢[1] 杨维平[1] 徐淑英 张畔[1] 

机构地区：[1]天津市第一中心医院妇产科

出　　处：《中国实用妇科与产科杂志》1998年第1期29-30,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的：探讨血浆置换术在重度妊高征治疗中的临床应用。方法：选择重度妊高征，妊娠３３周以后，临床治疗一周效果不明显的患者５例。用美国ＣＳ－３０００血细胞分离机进行血浆置换术。置换总量１０００～１６００ｍｌ，总置换时间２～４小时。置换液为新鲜血浆１０００～１６００ｍｌ，血小板１６Ｕ。结果：血浆置换后，血浆免疫物质（ＩｇＧ除外），肾素，血管紧张素，醛固酮，血栓素，前列环素，血、尿β２－ＭＧ均降低。肝、肾功能的各项化验无变化，ＩｇＧ升高。结论：血浆置换术为重度妊高征的治疗提供了一种全新的、先进的方法，达到了缓解症状、延长孕周、提高围产儿存活率、母婴安全的目的。Objective:To investigate the application of plasma exchange to the clinical treatment of severe pregnancy induced hypertension(PIH).Methods:5 women complicated with severe PIH after 33 gestational weeks who were treated unsuccessfully for l week by conventional therapy underwent plasma exchange using a U.S.model,the CS-3000 blood cell separator.A total volume of 1000～1600ml fluid containing fresh plasma 1000～1600ml and 16 units of platelets was exchanged during 2～4 hours.Results:After plasma exchange,there was a progressive decline of plasma immunological materials(except IgG which increased),such as renin,angiotension,aldosterone,thromboxane and prostacyclin,as well as blood and urinary β2-microglobulin.Liver and kidney functions did not change.Conclusion:It shows that plasma exchange provides a brand new and advanced method for the treatment of severe PIH.as it may prolong the gestational age,reduce symptoms and increase the perinatal survival rate.It is safe to both mother and fetus. \ \

关 键 词：血浆置换术 妊娠高血压 综合征 

分 类 号：R714.246[医药卫生—妇产科学] R457.1[医药卫生—临床医学]