参青方对三硝基苯磺酸诱导结肠炎大鼠肠道动力学的研究  

Study of ShenQing Recipe on intestinal motility in rat colitis induced by TNBS

作　　者：王臻楠[1] 戴彦成[1] 唐志鹏[1] 张亚利[1] 

机构地区：[1]上海中医药大学附属龙华医院中医药大学脾胃病研究所,上海200032

出　　处：《中国中西医结合消化杂志》2009年第1期15-17,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：上海市科学技术委员会科研基金(06411941);上海市教育委员会重点学科资助(J50305)

摘　　要：[目的]探讨参青方对三硝基苯磺酸(TNBS)诱导结肠炎大鼠肠道动力学异常的消炎作用及其调节肠道动力学的机制。[方法]用TNBS复制实验性大鼠结肠炎模型,随机分为参青方高剂量组、参青方低剂量组、美沙拉嗪(5-ASA)组、模型对照(模型)组及正常组,检测结肠肠管平滑肌条收缩频率、幅度。[结果]与正常组相比,造模各组大鼠结肠肠管平滑肌条收缩频率减少,幅度增加(均P<0.05);且参青方高、低剂量组及5-ASA组大鼠结肠肠管收缩频率和幅度均比模型组增加(均P<0.05)。[结论]TNBS诱导结肠炎大鼠出现肠管收缩频率和收缩波幅度异常;参青方能增加收缩频率和收缩波幅度,具有调节肠道动力学的作用。[Objective]To study the change of intestinal motility in trinitrobenzene sulfonic acid （TNBS） induced rat colitis and investigate the mechanisms underlying regulating the intestinal motility by ShenQing Recipe （SQR）. [Methods]The rat colitis induced by TNBS model was established. Rats were randomly divided into SQR high close group, SQR low dose group, 5-ASA group, model control group and normal group, the frequencey and amplitude of contraction wave of smooth muscle were examined. [Results] Compared with normal group, the frequencey of contraction wave of smooth muscle decreased while the amplitude increased in model group. The frequeneey and amplitude of contraction wave of smooth muscle both increased in SQR high dose group,SQR low dose group and 5-ASA groups. [Conclusion ]The frequencey and amplitude of contraction wave of smooth muscle become abnormal in rat colitis induced by TNBS. Our data indicates that the major mechanisms underlying the regulating the intestinal motility of SQR are by increasing the frequencey and amplitude of contraction wave of smooth muscle.

关 键 词：参青方 结肠炎 溃疡性 肠道动力学 

分 类 号：R289.5[医药卫生—方剂学] R574[医药卫生—中药学]