华东地区汉族人群早发急性冠脉综合征患者血小板反应素-4基因G29926C多态性分析  

Polymorphism of thrombospondin-4 gene in patients with premature acute coronary syndrome in eastern Chinese Han population

作　　者：高磊[1] 何国平[1] 杨国英[1] 戚传平[2] 马继政[3] 

机构地区：[1]江苏大学附属武进医院心内科,江苏省常州市213002 [2]江苏大学附属武进医院检验科,江苏省常州市213002 [3]南京医科大学第一附属医院心血管病研究所,210029

出　　处：《实用医学杂志》2009年第3期371-373,共3页The Journal of Practical Medicine

基　　金：常州市卫生局重大科研项目(编号:ZD200601)

摘　　要：目的:探讨中国华东地区汉族人群血小板反应素-4(thrombospondin-4,TSP-4)基因G29926C(A387P)多态性与早发急性冠脉综合征(ACS)发病的关联性。方法:应用聚合酶链反应-限制性片段长度多态性方法,检测102例早发ACS患者(病例组)和121例年龄及性别相匹配的非冠心病者(对照组)的TSP-4A387P多态性。结果:GC基因型在病例组和对照组的分布差异无统计学意义(5.9%vs7.4%,P=0.64),未检测到CC纯合子。C等位基因频率在病例组和对照组分别为2.9%、3.7%(P=0.65)。Logistic回归分析显示,TSP-4A387P多态性与早发ACS的发生无显著性相关(OR=0.71,95%CI:0.22～2.28,P=0.57)。结论:TSP-4基因387A→P变异在中国华东地区汉族人群中发生频率明显低于西方人群,且与早发ACS的发病无显著相关性。Objective To investigate the association between thrombospondin-4 （TSP-4） gene G29926C （A387P） polymorphism and premature acute coronary syndrome （ACS） in eastern Chinese Han population. Methods The polymorphism of TSP-4 gene A387P were measured by polymerase chain reaction and restriction fragment length polymorphism analysis （PCR-RFLP） in 102 patients with premature ACS （ACS group） and 121 non-coronary heart disease patients （control group）, who were matched in age and sex. Results The frequencies of GC genotype were 5.9% in ACS group and 7.4% in control group （P = 0.64）, and none of the CC homozygote was detected. The prevalence of C allele was 2.9% in ACS group and 3.7% in control group （P = 0.65）. Logistic regression analysis showed there was no significant correlation between TSP-4 gene A387P polymorphism and premature ACS （OR = 0.71, 95% CI： 0.22 - 2.28, P = 0.57）. Conclusion The mutation of TSP-4 gene 387A→P is dramatically lower in easter Chinese Han population in than in western populations, and is not significantly associated with the pathogenesis of ACS.

关 键 词：冠状动脉疾病 血小板反应素 基因多态性 聚合酶链反应 

分 类 号：R541.4[医药卫生—心血管疾病] R392.11[医药卫生—内科学]