缺氧诱导因子与妊娠期肝内胆汁淤积症  

Hypoxia Inducible Factors and Intrahepatic Cholestasis of Pregnancy

作　　者：李志芳[1] 倪观太[1] 

机构地区：[1]安徽省皖南医学院弋矶山医院妇产科,芜湖市241000

出　　处：《国际妇产科学杂志》2009年第1期23-26,共4页Journal of International Obstetrics and Gynecology

基　　金：安徽高校省级自然科学基金(KJ2008B322)

摘　　要：缺氧诱导因子(HIF)是广泛存在于人类细胞并调节细胞内氧代谢的关键因子,受缺氧信号调控,参与缺氧诱导多种基因的转录,目前研究较多的是HIF-1和-2。HIF类与正常妊娠胎盘胚胎的发育相关,其缺失或表达异常导致异常妊娠。妊娠期肝内胆汁淤积症(ICP)胎儿多有急慢性缺氧,近年对HIF类在ICP患者胎盘中作用开始有研究,其在胎盘中表达调节对维持胎盘功能起一定代偿作用,与该疾病发生发展有关。Hypoxia inducible factors （HIFs）are key proteins which are widely expressed in human cells.HIFs regulate cellular oxygen metabolism in response to hypoxia, and transcriptional responses of many genes to hypoxia are primarily mediated by the HIFs. The present study focuses on hypoxia-inducible factors-1 and -2. HIFs are crucial for placental development and embryogenesis during a normal pregnancy. The deficiency or abnormal expression of HIFs may lead to an abnormal pregnancy. Fetuses of women with intrabepatic cholestasis of pregnancy （ICP） experience more acute/less chronic hypoxia. Recent studies of the effects of HIFs on the placentas of patients with ICP have demonstrated that the expression and regulation of HIFs plays a compensatory role to maintain placental function. Thus, HIFs may be one of the hypoxia-related pathogenic factors during ICP development.

关 键 词：缺氧诱导因子-1Α 缺氧诱导因子-2Α 妊娠 胎盘 妊娠期肝内胆汁淤积症 

分 类 号：R714.2[医药卫生—妇产科学]