Toll样受体与女性生殖生理病理的研究进展  

Toll-like Receptors in Female Reproductive Physiology and Pathology

作　　者：王晓波[1] 徐键[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,杭州310006

出　　处：《国际妇产科学杂志》2009年第1期38-41,共4页Journal of International Obstetrics and Gynecology

基　　金：浙江省自然科学基金(Y2080397)

摘　　要：免疫系统与生殖系统间的相互作用对维持女性正常的生殖能力至关重要。越来越多的证据关注到Toll样受体(TLRs),TLRs是进化中比较保守的受体家族,不仅为生殖道免受外界病原体感染提供重要的保护作用,而且在生殖道维持基本的生理和病理作用过程中也发挥作用。近年对TLRs在女性生殖领域的研究增多。TLRs在女性卵巢、子宫内膜及胎盘中起关键性作用,同时与某些常见妇科疾病的发生也有关系。就TLRs在输卵管、子宫内膜、卵巢和胎盘的表达及可能的作用,以及TLRs在妇科常见疾病中发挥的作用综述。Interactions between the immune system and the reproductive system are important for maintaining female fertility and reproductive health in general. There is increasing evidence that the Toll-like receptors （TLRs）, which belong to conservative receptor family in evolution, are involved in this process. While there is no doubt that TLRs are important in providing protection against infections of the reproductive tract, there is increasing evidence for the involvement of TLRs in more basic pathology and physiology of reproduction. For example, TLRs have been implicated in critical aspects of ovarian, endometrial and placental function, as well as in common gynecological diseases. This review summarizes the current information available about the role of TLRs in reproductive physiology and pathology.

关 键 词：TOLL样受体 病原相关分子模式 免疫 生殖道 母胎界面 

分 类 号：R71[医药卫生—妇产科学]