LDL—C直接测定法与计算法的比较分析  

Analysis Comparing of Calculateds and Direct LDL Cholesterol Determination with Method

作　　者：叶桂云[1] 张忠源[1] 胡望平[2] 池细俤[1] 叶健频[1] 林坚[1] 

机构地区：[1]福建省南平市第一医院福建医科大学南平基地,福建南平353000 [2]南京军区福州总医院生化科,福州350025

出　　处：《现代检验医学杂志》2009年第1期55-58,共4页Journal of Modern Laboratory Medicine

摘　　要：目的寻找及评价更合适的低密度脂蛋白胆固醇（LDL—C）直接测定法或计算法。方法分析295例血清脂质结果。用直接法测定LDL—C和五种计算法比较。结果比较295例血清脂质分析，以Delong法与RANDOX直接测定法的LDL—C结果最接近（P〉0．05），差异无统计学意义。三酰甘油（TG）分组，当TG≤4．52mmol／L时，直接测定法较Delong法、Friedewald法高（P〈0．001），但Delong法最接近直接测定法。当TG〉4．52mmol／L时，多数计算法随TG增高而降低，但Delong法较稳定，比直接测定法高（P〈0．05）。以血清LDL—C分组，RANDOX直接测定法与Delong法公式计算法结果相符率（55．6％）最高。结论Delong法与RANDOX直接法的LDL—C最接近。当TG〉4．52mmol／L时，Delong法比其它方法结果稳定。Delong法比Friedewald法更适用于临床。Objective In order to deploy method and formula furthermore suitable on routine procedures. It is searched and evaluated that measured or formula calculation for LDL cholesterol（LDL-C） measurement. Methods Studied 295 cases of serum with LDL-C and TG concentrations. Evaluation of five calculation methods and RANDOX directly measured for determining LDL-C. Results It is not statistically significant （P〉0. 05） that different between RANDOX directly measured and Delong calculation in 295 cases LDL-C. In TG≤4.52 mmol/L,directly measured LDL-C is higher than Delong calculation,Friedewald calculation. But Delong calculation most approximation the directly measured LDL-C. In TG〉4.52 mmol/L,Delong calculation and directly measured LDL-C concentrations were significantly different （P〈0. 05）. The result conformity rate was 55.60/00 between RANDOX directly measured LDL-C and Delong calculation LDL-C. Conclusion The two LDL-C results is most approximation between RANDOX directly measured and Delong calculation. LDL-C of the Delong calculation is better stable than other methods. The Delong calculation is better refer to clinic than Friedewald calculation.

关 键 词：低密度脂蛋白胆固醇 Delong法 Friedewald法 直接测定法 公式计算法 

分 类 号：R446.112[医药卫生—诊断学]