定量检测N末端脑钠肽对心衰的诊断价值  

The clinical value of N-terminal pro-brain natriuretic peptide quantitative detection in diagnosis of heart failure

作　　者：汪隆海[1] 张平[2] 陈启松[3] 

机构地区：[1]安徽省含山县人民医院检验科,238100 [2]安徽省含山县人民医院彩超室,238100 [3]安徽省含山县人民医院心内科,238100

出　　处：《国际检验医学杂志》2009年第1期23-25,共3页International Journal of Laboratory Medicine

摘　　要：目的评价血清N末端脑钠肽(NT-proBNP)定量检测对心力衰竭患者的诊断价值。方法采用定量ELISA改进法检测不同心衰程度的患者血清NT-proBNP。结果心衰患者血清NT-proBNP水平明显增高,并随心衰患者程度加重呈指数增加;实验受试者工作特征曲线下面积为0.898;心衰的诊断敏感性和特异性分别为91.9%和92.3%。结论定量检测血清NT-proBNP是目前用于评价心衰患者的最佳实验手段。Objective To evaluate the diagnostic value of N terminal pro brain natriuretic peptide （NT-proBNP） quantitative detection in patients with heart failure. Methods Quantitative enzymelinked immunosorbent assay （ELISA） improvement method was applied to measuring serum level of NT-proBNP in patients with different degree of heart failure. Results The serum level of NT-proBNP was significantly elevated in patients with heart failure. With the increase of extent of heart failure, NT-proBNP increased in exponent. Receiver operator characteristic curve （ROC） showed that area un der curve （AUC） was 0. 898. The sensitivity and specificity were 91.90% and 92.3% respectively for diagnosis of heart failure. Conclusion Quantitative detection of NT proBNP is at present the best laboratory test for evaluating heart function of patients with heart failure.

关 键 词：利钠肽 脑 心力衰竭 充血性 诊断 

分 类 号：R446.61[医药卫生—诊断学] R541.61[医药卫生—临床医学]