环孢素诱导牙龈上皮细胞增生的机制  

Pathogenesis of Ciclosporin-induced gingival epithelial hyperplasia

作　　者：刘培红[1] 马肃[1] 

机构地区：[1]哈尔滨医科大学附属口腔医院牙周科,黑龙江哈尔滨150001

出　　处：《国际口腔医学杂志》2009年第1期81-83,共3页International Journal of Stomatology

基　　金：黑龙江省卫生厅科研课题基金资助项目(2006-009)

摘　　要：药物性牙龈增生(DGO)是由于服用免疫抑制剂、钙通道阻滞剂、抗癫痫药物等而引发的牙龈病变。传统意义上将DGO定义为服用某些药物引起的牙龈纤维增生和体积增大。近来发现,牙龈上皮细胞增厚也是引起DGO的重要原因之一。下文就环孢素抑制牙龈上皮程序性细胞死亡和促进牙龈上皮细胞增殖等机制作一综述。Drug-induced gingival overgrowth （DGO） is one of the gingival diseases because of suming immune depressant, calcium channel blocker and anti-epileptic drug. DGO was defined to gingival fibroplasia and enlargement in tradition. It was discovered that the gingival epithelial thickening was one of the important reasons of causing DGO recently. So the review on pathogenesis of Ciciosporiu-inhibited gingival epithelial apoptosis and Ciclosporin-accelerated gingival epithelial proliferation was made.

关 键 词：药物性牙龈增生 环孢素 上皮细胞 

分 类 号：R595.3[医药卫生—内科学] R781.4[医药卫生—临床医学]