糖依赖性胰岛素释放肽在脂肪代谢中的作用  

The role of glucose-dependent insulinotropic polypeptide in fat metabolism

作　　者：章志建[1] 洪洁[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢病科,200025

出　　处：《国际内分泌代谢杂志》2009年第1期5-7,10,共4页International Journal of Endocrinology and Metabolism

摘　　要：越来越多的研究表明，糖依赖性胰岛素释放肽（GIP）在脂代谢中具有重要的促合成作用，包括对葡萄糖摄取、脂肪酸合成、脂蛋白脂酶活性的刺激，造成脂肪酸在脂肪组织的沉积。同时，GIP可抑制胰高血糖素和异丙。肾上腺素诱导的脂肪分解，进而增加脂肪的堆积。在肥胖的动物模型中，长期阻断GIP的信号转导可以明显改善血糖、减轻体重，此外，还可减少高脂饮食诱导的肥胖的发生。以上研究结果为肥胖、糖尿病的预防和治疗提供了一种新的思路。Acumulative evidences indicate the anbolic effects of glucose-dependent insulinotropic polypeptide（GIP） in the fat metabolism,including stimulation of glucose uptake,lipoprotein lipase activity, fatty acid synthesis and incorporation into adipose tissue. Meanwhile, GIP inhibits both glucagon- and isoproterenol-induced lipolysis, thereby further favouring deposition rather than mobilisation of fat stores. Consistent with these various observations, chronic inhibition of GIP signal transduction can significantly improve the blood glucose and decrease body weight of obese animal models. In addition, it provides a protection from diet-induced obesity. And this may provide us a new approach for the prevention and treatment of obesity and diabetes mellitus.

关 键 词：糖依赖性胰岛素释放肽 肥胖症 糖尿病 脂蛋白脂酶 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]