丙型肝炎病毒感染性细胞模型的研究进展  

Progress in Establishment of HCV Infectious Cell Model

作　　者：王志强[1] 王怡[1] 詹林盛[1] 

机构地区：[1]军事医学科学院野战输血研究所,北京100850

出　　处：《生物技术通讯》2009年第1期99-102,共4页Letters in Biotechnology

基　　金：北京市自然科学基金(7082071)

摘　　要：丙型肝炎病毒(HCV)是造成慢性肝炎,肝硬化及肝癌的重要原因之一,目前全球约有1.7亿人感染HCV。然而缺乏有效的HCV感染模型,严重阻碍了对HCV致病机制的认识。最近几年以JFH1株和Huh-7细胞系为基础,通过对不同病毒株基因组的重组和细胞系的优化,进一步提高其感染能力,在HCV感染系统的建立上取得了突破性进展。我们简要综述近几年在HCV感染细胞模型方面取得的进展。Hepatitis C virus（HCV） is a major cause of chronic liver disease, such as chronic hepatitis, hepatic cirrhosis, hepatocellular carcinoma, with over 170 million persistently infected individuals worldwide. However, the lack of efficient infectious HCV cell models hampers our understanding in mechanisms of pathopoiesis. Recently by reconstruction of different isolates＇ genomes and optimization of host cell lines based on JFH1 isolate and Huh-7 cell line, there are many breakthroughs in infectious HCV culture system. Here the advances on establishment of HCV infectious cell models were reviewed.

关 键 词：丙型肝炎病毒 感染 细胞模型 

分 类 号：R392.1[医药卫生—免疫学]