盐酸戊乙奎醚对乙酰胆碱致离体大鼠子宫痉挛的影响  

Effect of penehyclidine hydrochloride on acetylcholine-induced contraction in isolated rat uterus

作　　者：肖洪涛[1,2] 廖治[3] 韩彬[2] 陈淑杰[2] 莫正纪[2] 

机构地区：[1]四川省医学科学院.四川省人民医院药剂科,成都610072 [2]四川大学华西药学院,成都610041 [3]四川省医学科学院.四川省人民医院妇产科,成都610072

出　　处：《中国新药杂志》2009年第2期163-166,共4页Chinese Journal of New Drugs

摘　　要：目的:评价盐酸戊乙奎醚对离体大鼠子宫收缩的影响。方法:采用乙酰胆碱(Ach)致大鼠离体子宫痉挛模型,测量给予盐酸戊乙奎醚后大鼠离体子宫条痉挛收缩的最大张力,用经典的Schild方法计算受试药的pA2值。实验同时使用非选择性胆碱受体阻滞剂阿托品和选择性M2受体阻滞剂加那胺(gallam ine)作阳性对照药。结果:盐酸戊乙奎醚的pA2值显著大于硫酸阿托品pA2值[(12.19±1.10)vs(9.36±2.30),P<0.05],与加那胺的pA2值接近(12.49±2.20)。盐酸戊乙奎醚对离体大鼠子宫抗Ach痉挛的松弛作用强度明显大于硫酸阿托品。结论:盐酸戊乙奎醚能有效地缓解离体大鼠子宫的痉挛状态。Objective： To investigate the effect of penehyclidine hydrochloride （PHC） on contraction in rat uterus. Methods： The contraction of isolated rat uterus was induced by acetylcholine. The maximum amplitude of contractions was measured after exposure to PHC, atropine （a non-selective M receptor antagonist） and gallamine （an M2 receptor antagonist）. The pA2 value was determined by Schild assay. Results： According to pA2 values, the antagonizing effect of PHC on acetylcholine-induced contraction in isolated rat uterus was stronger than that of atropine [ （12.19±1.10） vs （9.36±2.30）, P 〈0.05 ], and was similar to that of gallamine （12.49 ±2.20）. Conclusion： PHC can effectively relieve uterus contraction in vitro.

关 键 词：盐酸戊乙奎醚 离体子宫 pA2值 M受体阻滞剂 

分 类 号：R965.1[医药卫生—药理学] R971.92[医药卫生—药学]