高血压病患者血浆溶血磷脂酸水平研究  

The clinical study of plasma lysophosphatidic acid in patients with primary hypertension

作　　者：刘双梅[1] 宋达琳[1] 李梅[1] 牛力[1] 蔡尚郎[2] 

机构地区：[1]青岛大学医学院附属青岛市市立医院,山东青岛266011 [2]青岛大学医学院附属医院,山东青岛266011

出　　处：《中国医刊》2009年第2期34-35,共2页Chinese Journal of Medicine

摘　　要：目的探讨高血压病患者血浆溶血磷脂酸(LPA)水平的变化。方法入选原发性高血压病患者32例,按照2004年中国高血压防治指南作为诊断标准,并排除急性冠脉综合征、糖尿病、急性脑血管病及其他系统疾病,同时入选28例健康者作为对照组,分别测定高血压患者急性升高时与血压恢复稳定后血浆LPA水平,与正常对照组对比。结果高血压病组LPA均值水平分别为9.09±1.09μmol/L和2.56±0.22μmol/L,明显高于正常对照组2.41±1.22μmol/L,差异有显著性。高血压组患者急性血压升高时,LPA均值明显高于稳定时,差异有显著性。结论血浆中LPA作为体内凝血和血栓形成过程中血小板早期释放的分子标记物,在预测高血压患者血栓形成发生发展及指导临床合理应用抗血小板及抗凝药物方面可能有一定的指导意义。Objective To investigate the changing level of plasma lysophosphatidic acid （LPA） in patients with primary hypertension. Methods Observed 32 patients with primary hypertension were in acute heighten blood pressure and on the stabilization time, while observed 28 healthy person served as Control. Results Plasma LPA of hypertension group is significantly higher than that of control group. The Plasma LPA levels in suddenly step up blood pressure higher than that of stabilization time. Conclusion As a molecular marker released by activated platelet,Plasma LPA may be valuable for predicting the dangers and the development of thrombus or guide the treatment.

关 键 词：高血压病 溶血磷脂酸 血浆 

分 类 号：R541.6[医药卫生—心血管疾病]