国产与进口阿德福韦酯治疗拉米夫定耐药的慢性乙型肝炎药物经济学研究  

Homemade versus Imported Adefovir Dipivoxil for Patients with Chronic Hepatitis B Resistant to Lamivudine:A Pharmacoeconomic Study

作　　者：阳宇[1] 刘赛祥[1] 林山鹰[1] 

机构地区：[1]深圳市第一人民医院,深圳市518020

出　　处：《中国医院用药评价与分析》2009年第1期54-55,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:对国产与进口阿德福韦酯治疗拉米夫定耐药的慢性乙型肝炎进行经济学研究,选择最佳治疗方案。方法:对拉米夫定耐药的慢性乙型肝炎患者68例,随机分为两组,分别给予国产阿德福韦酯胶囊10 mg及进口阿德福韦酯片10 mg,每日1次,48周后观察临床疗效,运用药物经济学的最小成本分析、成本-效果分析方法进行评价。结果:两组临床疗效无显著性差异,但两组药物成本有显著差异。结论:治疗拉米夫定耐药的慢性乙型肝炎,国产阿德福韦酯胶囊有经济学优势。OBJECTIVE： To conduct a pharmacoeconomic study on homemade versus imported Adefovir Dipivoxil in the treatment of patients with chronic hepatitis B resistant to Lamivudine so as to optimize the therapeutic scheme. METHODS： A total of 68 patients with chronic hepatitis B resistant to Lamivudine were randomly assigned to receive homemade Adefovir Dipivoxil Capsule （10mg） or imported Adefovir Dipivoxil Tablet （10mg） qd for 48 weeks. Then cost-minimization analyses and cost-effectiveness analyses were conducted to compare the pharmacoeconomic efficacy between the two groups. RESULTS： There was no significant difference in clinical efficacy but was in drug cost between the two groups. CONCLUSION ： The homemade Adefovir Dipivoxil Capsule had the pharmacoeconomic advantages over the imported Adefovir Dipivoxil Tablet in the treatment of patients with chronic hepatitis B resistant to Lamivudine.

关 键 词：阿德福韦酯 国产 进口 乙型肝炎 药物经济学 

分 类 号：R969.4[医药卫生—药理学]