注射用盐酸头孢吡肟与4种常用输液配伍的稳定性研究  

Stability study of Cefepime Hydrochloride Injection combined with four common used liquids

作　　者：刘诗琼[1] 王文渊[1] 李世胜[2] 

机构地区：[1]永州职业技术学院药学系,湖南永州425006 [2]永州职业技术学院附属医院,湖南永州425006

出　　处：《中国医药导报》2009年第4期15-17,共3页China Medical Herald

摘　　要：目的:使用高效液相色谱法(HPLC)研究注射用盐酸头孢吡肟与4种常用输液配伍的稳定性。方法:盐酸头孢吡肟与4种输液按临床应用配伍,考察室温下12h内溶液的pH值及外观变化,采用HPLC法考察头孢吡肟的含量变化。结果:在室温条件下,与生理氯化钠溶液配伍后,6h内基本稳定;与10%葡萄糖、5%葡萄糖氯化钠和5%葡萄糖配伍后,随着时间的延长,8h内含量分别降至96.11%、97.06%和96.51%。结论:注射用盐酸头孢吡肟可与生理氯化钠溶液配伍使用,但应在6h内用完。Objective： To investigate the stability between Cefepime Hydrochloride Injection and the four common used hquids in clinic by HPLC. Methods： Cefepime Hydrochloride Injection was combined with four liquids according to the clinical application, and the changes of pH value and the appearance of liquids 12 h under room temperature were observed, and then HPLC was employed to investigate the content change of Cefepime Hydrochloride Injection. Results： Under room temperature, the mixture of Cefepime Hydrochloride Injection and physiological solution of sodium chloride was almost stable within 6h; the contents of Cefepime Hydrochloride Injection in the mixture of 10% glucose solution, 5% glucose sodium chloride solution and 5% glucose solution was decreased to 96.11%, 97.06% and 96.51% respectively along with the time within 8 h. Conclusion： Cefepime Hydrochloride Injection can be used with physiological solution of sodium chloride, but it must be used up in 6h.

关 键 词：高效液相色谱法 注射用盐酸头孢吡肟 稳定性 

分 类 号：R942[医药卫生—药剂学]