射频毁损术中近红外实时监测技术基础研究  

Basic research of real-time monitoring in radio frequency neurosurgery by near-infrared technology

作　　者：程业果[1] 钱志余[1] 杨天明[2] 吴琦[2] 曹清华[1] 

机构地区：[1]南京航空航天大学生物医学工程系,江苏南京210016 [2]东南大学附属中大医院,江苏南京210009

出　　处：《量子电子学报》2009年第1期97-101,共5页Chinese Journal of Quantum Electronics

摘　　要：利用近红外光谱(Near infrared spectrum,NIRS)测量技术进行射频损毁术中实时监测技术研究,探讨立体定向术中损毁疗效评估的可行性。在进行丘脑腹外侧核(Ventrolateral Thalamus,Vim)毁损术射频损毁的同时,使用近红外光谱实时采集系统检测在损毁过程中吸收系数(μ_a)与优化散射系数(μ′_s)的变化情况。结果表明:44℃射频损毁过程中吸收系数和优化散射系数增大,停止损毁后逐步恢复,稳定后μ_a和μ′_s稍高于初始值;70℃射频损毁时μ_a和μ′_s增大,停止损毁且稳定后保持不变。根据μ_a和μ′_s的变化规律进行立体定向毁损过程实时监测是非常有可能的。To explore and validate the feasibility of in vivo real-time monitoring for brain tissue properties in stereotaxic radio frequency （RF） neurosurgery by near infrared spectrum technique, the change of absorption coefficient （μa） and reduced scattering coefficient （μ′s） of brain tissue is measured real-time by minimal invasive near infrared spectrum system in RF lesion of thalamotomy. The result indicates that absorption coefficient and reduced scattering coefficient increased when RF heating temperature was kept at 44 ℃, and μa and μ′s decreased slowly when RF lesion was stopped, and the value of μa and μ′s was a litter higher corresponding to the original value at the balance level. μa and μ′s kept in the high level when the RF lesion temperature was set in 70 ℃. The μa and μ′s real-time and in vivo monitoring for brain tissue by near infrared spectrum in stereotaxic RF neurosurgery is feasible.

关 键 词：光谱学 射频损毁 吸收系数 实时监测 

分 类 号：O434.13[机械工程—光学工程] Q631[理学—光学]