福辛普利对老年冠心病患者内皮功能影响的临床观察  

Clinical Observation of Fosinopril on Vascular Endothelial Function in Elderly Patients with Coronary Heart Disease

作　　者：王敏莲[1] 邓凤梅 

机构地区：[1]武汉大学人民医院,码武汉430060 [2]湖北省省直机关门诊部

出　　处：《微循环学杂志》2009年第1期39-40,共2页Chinese Journal of Microcirculation

摘　　要：目的:观察血管紧张素转换酶抑制剂福辛普利对老年冠心病患者血管内皮功能的影响。方法:30例老年冠心病患者口服福辛普利(1次/日,5～10mg/次)治疗8个月前后检测血浆内皮素-1(ET-1)浓度变化和肱动脉内皮依赖性舒张反应。结果:药物治疗8个月后,患者血浆ET-1浓度由117.00±12.00Pg/ml下降至93.00±9.77Pg/ml(P<0.05);充气后反应性肱动脉内径增加率由5.20±2.70%上升为12.00±3.00%(P<0.01)。结论:福辛普利治疗能够改善老年冠心病患者的内皮功能。Objective:To investigate the effect of therapy with fosinopril on vascular endothelial function in elderly patients with coronary heart disease.Method:Thirty patients with coronary heart disease were treated with fosinopril for 8 months.Before treatment and after 8 months of treatment,the concentration of endothelin-1(ET-1)was measured.The endothelium-dependent relaxation response of the right brachial artery was assayed with color Doppler ultrasound.Results:After 8 months of treatment with fosinopril,the concentration of ET-1 was decreased from(117.00±12.0)pg/ml to(93.00±9.77)pg/ml(P<0.05).The diameter of brachial artery in responding to reactive hyperemia was improved greatly from(5.2±2.7)% to(12.0±3.0)%(P<0.05).Conclusion:Therapy with fosinopril can effectively improve vascular endothelial function in elderly patients with coronary heart disease.

关 键 词：老年冠心病患者 福辛普利 内皮功能 临床观察 血管紧张素转换酶抑制剂 肾素-血管紧张素系统 血管平滑肌细胞增殖 内皮依赖性舒张反应 

分 类 号：R541.4[医药卫生—心血管疾病] R544.1[医药卫生—内科学]