非清髓性造血干细胞移植应用抗胸腺细胞球蛋白/抗淋巴细胞球蛋白的观察和护理  

Observation and nursing of use of anti-themocyte globulin/anti-lymphocyte globulin in nonmyeloablative transplantation

作　　者：邓秀云[1] 周素贞[1] 彭群英[1] 严早健[1] 

机构地区：[1]广东省广州市第一人民医院血液内科,广东广州510180

出　　处：《吉林医学》2009年第2期103-104,共2页Jilin Medical Journal

摘　　要：目的:观察抗胸腺细胞球蛋白(ATG)/抗淋巴细胞球蛋白(ALG)在非清髓性造型干细胞移植应用过程中的不良反应并提高其护理水平。方法:在18例非清髓性异基因造血干细胞移植(NST)的预处理中对ATG/ALG进行观察及相关护理。结果:6例皮试阳性,12例皮试阴性。在应用过程中,多数病例出现发热、寒颤、皮疹等反应,4例出现血清病,8例出现血压下降,经预防性用药及监护处理,顺利完成ATG/ALG治疗;结论:只要做好充分的预防措施及严密的监控护理,能顺利完成NST的预处理,保证基因造血干细胞移植的顺利。Objective To observe the side -effects of using anti -themocyte globulin （ATG） /anti -lymphocyte globulin （ALG） in nonmyeloablative transplantation and to improve nursing levels. Method Using of ATG/ALG in the course of conditioning regiments of nonmyeloablative stem cell transplantation （NST） on 18 patients were observed. Results Positive and negative reactions of subtaneous tests were 6 and 12 cases, respectively. Most of the patients had fever, chills and skin rashes during the use of ATG/ALG. Four patients developed serum diseases, 8 had blood pressure decreasing. All the patients smoothly finished the projects by means of monitoring and prophylactic treatment. Conclusion Conditioning regiments of NST are enable to be smoothly finished in order that the allo - haemotopoietic stem cell transplants is ensured to be succeeded if adequate prophylaxes and carefully monitors are performed.

关 键 词：非清髓性 造血干细胞移植 ATG/ALG 护理 

分 类 号：R473[医药卫生—护理学]