1-乙酰基-3-烷基薁类衍生物的合成  

Synthesis of 1-acetyl-3-alkylazulene derivatives

作　　者：谷峥[1] 王道林[1] 黄孝东[1] 韩珊[1] 徐姣[1] 

机构地区：[1]渤海大学化学化工学院辽宁省应用化学重点实验室,辽宁锦州121003

出　　处：《化学试剂》2009年第2期135-136,共2页Chemical Reagents

摘　　要：以环庚并呋喃-2-酮-3-羧酸酯为初始原料,在分子筛的催化作用下,与脂肪醛、吗啡啉进行[8+2]环化加成,制得3-烷基薁-1-羧酸甲酯,采用三氯乙酸进行脱羧反应,得到1-烷基薁,最后经Vilsmeier-Haack反应,在N,N-二甲基乙酰胺和三氯氧磷作用下得到高收率的标题化合物。1-Acetyl-3-alkylazulenes were obtained by the Vilsmeier- Haack reaction of l-alkylazulenes, which were obtained via the [ 8 ＋ 2 ] cycloaddition reaction of methyl 2H-eyclohepta- [ b ] faran- 2-one-3-carboxylate with alkylaldehydes and morpholine in the presence of molecular sieves followed by decarboxylation reaction in the presence of trichloroacetic acid with good yield.

关 键 词：乙酰基薁 Vilsmeier-Haack反应 [8+2]环化加成 分子筛 合成 

分 类 号：O626[理学—有机化学]