氟胺草酯合成工艺路线的改进研究  

Study on new synthesis process of flumiclorac-pentyl

作　　者：屠美玲[1] 郑敏[1] 夏波[1] 沈德隆[1] 

机构地区：[1]浙江工业大学农药研究所,浙江杭州310032

出　　处：《浙江工业大学学报》2009年第2期152-155,共4页Journal of Zhejiang University of Technology

摘　　要：氟胺草酯是由日本住友化学公司开发的酞酰亚胺类超高效除草剂,适用于防除大豆、玉米等作物田的杂草.在传统工艺路线的基础上,以对氟苯酚为原料,经过氯化、醚化、硝化、还原、缩合五步反应得到高效除草剂氟胺草酯,产品总收率达到33%,含量95%.产品及其中间体结构均通过元素分析1、H NMR,MS和IR确证.As one kind of tetrahydrophthalimide herbicides with high efficiency to control the weed in corn and soybean fields, flumiclora-pentyl was firstly synthesized by Sumitomo Chemical. Based on the traditional synthesis process, using p-fluorophenol as a starting material, a new synthesis process of flumiclora-pentyl was developed with several steps such as chlorination, etherification, nitrification, reduction and condensation. The yield of the product was 33%, and the purity was higher than 95%. The structures of the product and the intermediate were confirmed by Elementary Analysis, ^1H-NMR, MS and IR methods.

关 键 词：氟胺草酯 硝化 对氟苯酚 除草剂 

分 类 号：TQ460.3[化学工程—制药化工]