分子烙印技术分离识别生物碱成分的研究进展  

The recent research progress in separation and recognition of alkaloids by molecular imprinting technique

作　　者：单伟光[1] 张轶[1] 唐岚[1] 占扎君[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310032

出　　处：《浙江工业大学学报》2009年第1期1-5,共5页Journal of Zhejiang University of Technology

基　　金：浙江省新苗人才计划资助项目(2007G60G2020021);浙江省自然科学基金资助项目(Y206825)

摘　　要：分子烙印技术是高分子科学、材料科学、生物学和化学工程等学科的有机结合.该技术以目标烙印分子为模板,选用能与目标烙印分子产生特定相互作用的功能性单体,在烙印分子周围与交联剂进行聚合,形成三维交联的聚合物网络.通过萃取除去烙印分子,在聚合物网络中形成形态和化学功能团与烙印分子互补的孔穴,其对烙印分子具有特殊的亲合性.从分子烙印技术的历史发展及其在分离识别生物碱成分中的研究进展方面进行了综述,并展望了分子烙印技术在该领域的发展趋势.Molecular imprinting technique （MIT） is a new field which originates froni multiple disciplines such as macromolecule science, material science, biology and chemical engineering. The target molecule and functional monomer were polymerized by a cross-linking agent to form 3D network. And the cavity which has the same forms and the functional groups were shaped in the network by extracting the target molecule. The molecular imprinted polymers have special hydrophilicity. The article reviews the origin of MIT and the recent research progress in separation and recognition of alkaloids by molecular imprinting technique. The trend of MIT in pharmaceutical sciences is also forecasted.

关 键 词：分子烙印聚合物 生物碱 选择性识别 综述 

分 类 号：R282.2[医药卫生—中药学]