Effects of Abnormal Early Rearing Environments on Fear Memory in Adult Rats  

大鼠成年前异常生活环境对其成年后恐惧记忆的影响(英文)

作　　者：李传玉[1,2] 张波[3] 李振邦[1] 黄伏连[1] 田绍文[1] 胡新天[2] 

机构地区：[1]南华大学医学院生理教研室,湖南衡阳421001 [2]中国科学院昆明动物研究所灵长类感觉-运动整合及动物模型和人类疾病机制重点实验室,云南昆明650223 [3]中国科学院昆明动物研究所灵长类认知实验室及动物模型和人类疾病机制重点实验室,云南昆明650223

出　　处：《Zoological Research》2009年第1期31-37,共7页动物学研究（英文）

基　　金：National Natural Science Foundation of China(30770689);Scientific Research Fund of Hunan Provincial Education Department (05B045);National Basic Research Program of China (2002CB410803-04)

摘　　要：In the present experiment, Pavlovian fear conditioning was adopted to study the effects of different early rearing environments on fear conditioning in adult rats. Weaned rats were reared in three manipulable environments （enriched, social and isolated conditions）. After 8 weeks, fear conditioning （characterized by percentage of freezing） was observed and analyzed, and rats＇ weight, locomoter activity and foot-shock sensitivity were operated too. The results showed that： （1） Compared with control group, the level of conditioned fear was significantly increased in enriched group, but significantly decreased in isolated group; （2） Enriched and isolated conditions influenced rat＇s weight significantly; （3） Different rearing conditions have no effect on locomoter activity and foot-shock sensitivity. These results indicated that early enriched condition could improve the tone-evoked fear conditioning response, while isolated condition impaired the response.为了探讨早期饲养环境对成年后大鼠条件化恐惧的影响,实验采用巴氏恐惧条件化的方法对不同饲养环境下的大鼠进行了行为检测。具体操作为:把断奶后的大鼠饲养在3个不同的人工控制的环境中(丰富环境、社群环境和贫瘠环境);8周后进行恐惧条件化训练和测试(指标为僵直百分比),以及检测不同饲养环境下的大鼠的体重、自发活动和足部电击敏感性。结果显示:与社群组相比,丰富组的大鼠条件化僵直水平明显增加,而贫瘠组的明显减少;丰富和贫瘠环境明显的影响了大鼠的体重;不同环境对自发活动和足部电击敏感性没有影响。这些结果说明幼年期的丰富环境能提高成年后大鼠的由声音诱发的条件化恐惧反应,而贫瘠环境则削弱了这种反应。

关 键 词：Fear conditioning FREEZING Enriched condition Isolated condition Locomoter activity Foot-shock sensitivity 

分 类 号：Q42[生物学—神经生物学] Q959.837[生物学—生理学]