131例妊娠期肝内胆汁淤积症的围生结局分析  

Perinatal Outcomes of Intrahepatic Cholestasis of Pregnancy:Analysis of 131 Cases

作　　者：邓妮[1] 侯红瑛[1] 梅志雄[1] 刘雪凌[1] 

机构地区：[1]中山大学附属第三医院,广东广州510630

出　　处：《实用妇产科杂志》2009年第1期34-36,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨及早发现羊水胎粪污染及适时终止妊娠对妊娠期肝内胆汁淤积症(ICP)围生结局的影响。方法:对131例ICP病例资料进行回顾性分析。结果:共发现羊水胎粪污染49例,其中羊膜腔穿刺发现6例,人工破膜发现34例,剖宫产手术中发现4例,自然破膜发现5例。羊水污染率37.4%,早产率26.0%,剖宫产率62.6%,均高于同期分娩的非ICP患者(P<0.05)。3例新生儿Apgar 1分钟评分小于7分,无围生儿死亡。围生儿死亡率低于一些较大样本的文献累计的ICP围生儿死亡率(P<0.05)。结论:及早发现羊水胎粪污染及适时终止妊娠,对降低ICP患者围生儿死亡率具有重要的临床价值。Objective：To explore the influence of early detection of rneconium stained amnionic fluid and timely termination of pregnancy on perinatal outcomes of intrahepatic cholestasis of pregnancy （ICP）. Methods： The clinical data of 131 cases of ICP were retrospectively analyzed. Results： Meconium passage was documented in 49 cases, 6 of which ware detected by amniocentesis, 34 by induced rupture of membrane, 4 by cesarean section, and 5 by spontaneous rupture of membrane. The rate of meconium-stained amniotic fluid was 37.4%, premature delivery 26.0%, and cesarean section 62.6%, all of which were significantly higher in ICP patients than in normal pregnant population of the same gestational age （ P 〈 0.05）. There was no fetal death in the 131 cases, 3 cases hadApgar score below 7 at 1 minute. The perinatal mortality rate was significantly lower than in the cumulative series （ P 〈 0.05）. Conclusions： Early detection of meconium stain and termination of pregnancy at proper time has clinical value in decreasing perinatal mortality in ICP.

关 键 词：妊娠期肝内胆汁淤积症 妊娠结局 羊水胎粪污染 

分 类 号：R714.255[医药卫生—妇产科学]