宫颈电圈环切术对妊娠结局影响的Meta分析  

A Meta Analysis of Pregnancy Outcome after Loop Electrosurgical Excision Procedure

作　　者：王娟[1] 胡建铭[1] 

机构地区：[1]苏州大学附属第一医院,江苏苏州215006

出　　处：《实用妇产科杂志》2009年第1期41-43,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨宫颈电圈环切术(LEEP)对妊娠结局的影响。方法:通过计算机检索1990～2007年国内外公开发表的有关宫颈LEEP术对妊娠结局影响的相关文献,采用荟萃(Meta)分析的方法,对入选的8篇外文文献中病例对照研究进行定量综合分析。应用RevMan 4.2统计软件计算合并优势比(OR)及95%可信区间(CI)。结果:①LEEP术组的早产发生危险度是对照组的1.56倍(合并OR=1.56,95%CI为1.26～1.92);②LEEP术组孕周<37周的胎膜早破(pPROM)发生危险度是对照组的3.17倍(合并OR=3.17,95%CI为2.12～4.74);③LEEP术组的低体重儿(LBW)发生危险度是对照组的1.60倍(合并OR=1.60,95%CI为1.16～2.22);④无证据表明LEEP术将会影响剖宫产率(合并OR=0.95,95%CI为0.75～1.15)。结论:LEEP术可增加术后妊娠早产、pPROM、LBW发生率,对剖宫产率没有影响。Objective：To investigate the influence of loop electrosurgical excision procedure （LEEP） on subsequent pregnancy outcomes. Methods： 8 published case-control references about pregnancy outcomes after loop electrceurgical excision procedure from 1990 to 2007 were collected. Meta-analysis method was applied with RevMan4.2 software to calculate the odds ratio. Results：The incidence of preterm birth in LEEP group was 1.56 times of that in control （overall OR = 1.56, 95% CI： 1.26 - 1.92） ; the incidence of premature PROM was 3.17 times of that in control （overall OR = 3.17, 95% CI. 3.12 -4.74）; and the incidence of low birth weight infants was 1.60 times of that in control （overall OR = 1.60, 95% CI; 1.16 - 2.22）. There was no difference in cesarean delivery rate （overall OR = 0.95, 95% CI; 0.75 - 1.15） .Conclusions.Women who had LEEP were more likely to have preterm birth, premature PROM, and low birth weight infants, but there was no difference in cesarean delivery rate.

关 键 词：宫颈电圈环切术 早产 荟萃分析 

分 类 号：R713.4[医药卫生—妇产科学]