2型糖尿病患者餐后高甘油三酯血症对早期动脉粥样硬化形成的影响  

Relationship between postprandial hypertriglyceridemia and early atherosclerosis in type 2 diabetic patients

作　　者：蒋钰[1] 李春明[1] 

机构地区：[1]江西省宜春学院医学院,宜春336000

出　　处：《郑州大学学报（医学版）》2009年第1期140-142,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨2型糖尿病患者餐后高甘油三酯血症对早期动脉粥样硬化形成的影响,为预防糖尿病大血管病变提供理论依据。方法:2型糖尿病患者95例,按空腹甘油三酯和脂肪餐试验4h后甘油三酯水平分为餐后正常组、餐后增高组、空腹高脂组,所有患者均测空腹血糖、餐后2h血糖、空腹血胰岛素、糖化血红蛋白、总胆固醇、甘油三酯、高密度脂蛋白-胆固醇,低密度脂蛋白-胆固醇、体质量指数、腰臀比、血压,计算胰岛素敏感指数,测量颈动脉内膜-中层厚度。以颈动脉内膜-中层厚度为因变量,其他指标为自变量,进行多元线性相关分析。结果:餐后增高组、空腹高脂组颈动脉内膜-中层厚度分别为(1.23±0.64)mm、(1.12±0.63)mm,均高于餐后正常组[(0.75±0.63)mm](P<0.05),而餐后增高组与空腹高脂组颈动脉内膜-中层厚度差异无统计学意义(P>0.05)。颈动脉内膜-中层厚度与餐后4h血甘油三酯水平、空腹血胰岛素、体质量指数、腰臀比有相关性(P<0.01)。结论:2型糖尿病餐后高甘油三酯血症是导致早期动脉粥样硬化病变发生发展的一个重要危险因素。Aim ： To explore the effect of postprandial hypertriglyceridemia on the early atherosclerosis in type 2 diabetic patients, and to provide a theoretical basis for the clinical prevention of diabetic macroangiopathy. Methods：According to blood triglyceride （TG） level （fasting TG and TG 4 h） ,95 diabetic patients were divided into three groups：postprandial normal group, postprandial increased group, fasting high-fat group. All patients＇ fasting plasma glucose, postprandial 2- hour blood glucose, fasting plasma insulin, HbAlc, total cholesterol, total triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, body mass index, waist-hip, ratio, blood pressure were measured; insulin sensitivity index was calculated;and carotid artery intima-media thickness were measured. Correlation analysis between carotid artery intima-media thickness and other parameters were performed. Results： Carotid artery intima-media thickness in postprandial increased group and fasting high-fat group were significantly higher than that in postprandial normal group （ P 〈 0.05 ）, which had no difference between increased postprandial group and fasting high-fat group（ P 〉 0.05 ） ;multiple correlation analysis showed that carotid artery intima-media thickness was correlated with TG 4 h ,fasting plasma insulin, BMI and WHR （P 〈 0.01 ）. Conclusion： Type 2 diabetes postprandial hypertriglyceridemia is an important risk factor leading to early atherosclerosis.

关 键 词：2型糖尿病 餐后高脂血症 颈动脉内膜-中层厚度 

分 类 号：R587.1[医药卫生—内分泌]