调脂胶囊对实验性动脉粥样硬化大鼠主动脉ICAM-1表达的影响  

Influence of Tiaozhi capsule on expression of ICAM-1 in rats

作　　者：谢宁[1] 杨思进[2] 白雪[2] 李洪林[1] 秦大连[1] 陈美娟[1] 

机构地区：[1]泸州医学院药学院,四川泸州646000 [2]泸州医学院附属中医院,四川泸州646000

出　　处：《西部医学》2009年第2期185-187,共3页Medical Journal of West China

摘　　要：目的探讨调脂胶囊抗动脉粥样硬化的作用及其机制。方法用维生素D3和高脂饲料诱发大鼠动脉粥样硬化。雄性SD大鼠随机分为正常组,模型组,调脂胶囊高,中,低剂量组及辛伐他汀组。给药10周后,酶比色法检测各组大鼠血清和组织超氧化物歧化酶(SOD)活性和丙二醛(MDA)的含量。RT-PCR方法检测主动脉壁ICAM-1 mRNA表达水平。结果治疗组MDA含量均明显降低,SOD活性增高。调脂胶囊能减少ICAM-1基因的表达,且高剂量组作用更为明显。结论调脂胶囊具有抗动脉粥样硬化作用,其抗氧化和下调主动脉ICAM-1表达可能是其作用机制之一。Objective To investigate the mechanism of anti-atherosclerosis of Tiaozhi capsule. Methods 60 male SD rats were randomly divided into 6 groups, including control group, model group, simvastatin group, high dose Tiaozhi group, middle dose Tiaozhi group and low dose Tiaozhi group. The model of atherosclerosis was established with feeding high cholesterol diet and vitamin D3. After 10 weeks, the super oxide dismutase （SOD） and maleic dialdehyde （MDA） were detected with enzyme colorimetric method. ICAM-1-mRNA in aortic wall was detected with RT-PCR. Resuits SOD of groups treated with Tiaozhi obviously increased compare with those of model group, whereas MDA decreased. The levels of ICAM-1 mRNA in each treated group were significantly lower than that in model group. The high dose Tiaozhi group demonstrated much better results than the other groups. Conclusion Tiaozhi capsule shows effects of anti-atherosclerosis, whose mechanism maybe involve in down-regulating the expression of ICAM-1 in artery vessels.

关 键 词：调脂胶囊 动脉粥样硬化 细胞间粘附分子 氧自由基 

分 类 号：R33[医药卫生—人体生理学]