辛伐他汀对不稳定性心绞痛患者C-反应蛋白和血脂的影响  

Effects of simvastatin on C-reactive protein and hyperlipodemia in patients with unstable angina

作　　者：李勇[1] 柴天桥[1] 杨大春[2] 

机构地区：[1]广元市朝天区人民医院心内科,四川广元628012 [2]成都军区总医院心内科,四川成都610083

出　　处：《西部医学》2009年第2期216-217,共2页Medical Journal of West China

摘　　要：目的探讨辛伐他汀对不稳定性心绞痛（UAP）患者的C-反应蛋白及血脂的影响。方法选择65例诊断明确的不稳定性心绞痛患者，随机分成两组，在常规治疗的基础上治疗组给予辛伐他汀（苏之，成都华宇制药有限公司生产）10-20mg，每日晚顿服，用药5周后观察治疗前后C-反应蛋白及血脂浓度的变化。结果使用辛伐他汀治疗后的患者血清C-反应蛋白、总胆固醇、甘油三脂、低密度脂蛋白显著降低、高密度脂蛋白上升。结论辛伐他汀能有效降低CRP和血脂水平，对冠心病患者具有多重治疗作用。Objective To observe the effects of simvastatin on C-reactive protein and hyperlipodemia in patients with unstable angina. Methods 65 patients with unstable angina were randomly divided into two groups, including control group and simvastatin group. The control group was treated with normal therapy, whereas simvastatin group was treated with normal therapy and simvastatin. The serous C-reactive protein and lipid were monitored before and after treatment. Results Simvastatin could significantly decrease the level of CRP, TG, TC, LDL and increase the level of HDL. Conclusion Simvastatin can decrease CRP and hyperlipodemia.

关 键 词：辛伐他汀 不稳定性心绞痛 C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]