坦索罗辛在上段输尿管结石体外冲击波碎石术后排石中的作用  

Tamsulosin increases success rate of extracorporeal shock wave lithotripsy of proximal ureteral calculi

作　　者：桂西青[1] 郭振宇[1] 孙华宾[1] 练文飞[1] 张斌[2] 

机构地区：[1]中山大学附属第五医院泌尿外科,广东省珠海市519000 [2]中山大学附属第五医院胸心外科,广东省珠海市519000

出　　处：《中国医药》2009年第2期140-142,共3页China Medicine

摘　　要：目的评估坦索罗辛在上段输尿管结石体外冲击波碎石术（ESWL）后排石中的作用。方法126例上段输尿管结石患者接受单次ESWL后按随机登记号分配为实验组和对照组。实验组予坦索罗辛0．4mg／d，口服，对照组不服用药物。随访4周，观察结石排净率、结石排净时间、再发肾输尿管绞痛需使用镇痛剂的情况。结果实验组和对照组分别有2例和1例退出研究。实验组和对照组结石排净率分别为98．4％（60／61）和87．1％（54／62），组间差异有统计学意义（P〈0．05）；结石排净时间分别为（7．5±6．6）d和（11．5±7．2）d，2组差异有统计学意义（P〈0．01）；再发绞痛需要使用镇痛剂率分别为9．84％（6／61）和33．9％（21／62），差异有统计学意义（P〈0．01）。结论上段输尿管结石行ESWL后给予坦索罗辛治疗，可以缩短结石排净时间、减少并发症、提高结石排净率。Objective To evaluate the clinical effect of tamsulosin in extracorporeal shock wave lithotripsy （ESWL） of proximal ureteral calculi. Methods A hundred and twenty-six patients with proximal ureteral calculi underwent a single ESWL session were randomized into treatment group and control group. Patients in treatment group received tamsulosin （0.4 mg per day）, and no tamsulosin in control group. Both of them were followed up for 4 weeks. Results Two cases in treatment group and one case in control group withdrew from the study. The stonefree rate was 98.4% （60/61） in treatment group and 87.1% （54/6） in control group （P 〈0.05 ）. A mean stone- clearance time of control group was （11.5 ±7 ） days, higher than treatment group （4.6± 7days） （P 〈 0.01 ）. Rates of renoureteral colic needing analgesic were 9.84% （6/61） and 33.9% （1/6） respectively in treatment group and control group （P 〈 0.01 ）. Conclusion For extracorporeal shock wave lithotripsy of proximal ureteral calculi, tamsulosin increases the stone-free rate, reduces mean stone-clearance time and the occurrence of renoureteral colic recurred needing analgesic.

关 键 词：上段输尿管结石 坦索罗辛 体外冲击波碎石术 

分 类 号：R693.4[医药卫生—泌尿科学]