高渗诱导因子NFAT5  

Hypertonicity Response Factor NFAT5

作　　者：张悦[1] 侯林[1] 李楠[1] 伊男[1] 王海山[1] 陈文博[1] 

机构地区：[1]辽宁师范大学生命科学学院,辽宁大连116029

出　　处：《动物医学进展》2009年第2期64-68,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(30271035)

摘　　要：NFAT5是Rel蛋白家族中目前最后一个被发现的成员,也是转录因子NFAT家族中惟一在哺乳动物细胞中调控由渗透压诱导的基因表达的成员。它以二聚体的形式与DNA形成蝶状复合体结构,通过磷酸化被激活,并受多种激酶的调控,对于维持高渗条件下细胞内的渗透压平衡具有极为重要的作用。论文就NFAT5的结构、功能以及调控机制等进行综述。NFAT5 is discovered as the last member of Rel protien family, and also is the only member of transcription factor NFAT family which can regulate the gene expression that is induced by hypertonicity in mammal cells. NFAT5 binds DNA as a dimer in a conformation similar to the butterfly mode. It is activated by phosphprylation,and is regulated by many kinds of kinases. NFAT5 is necessary for cells to maintain the osmotic balance. This article summerized the configuration,function and regulation mechanism of NFAT5.

关 键 词：NFAT5蛋白 渗透压 基因转录 

分 类 号：S852.2[农业科学—基础兽医学] S852.33[农业科学—兽医学]