毛冬青中三萜皂苷类化合物的NMR归属  

NMR Assignment for Triterpenoids Saponins from the Root of Ilex pubescens

作　　者：张翠仙[1] 杨金燕[1] 林朝展[1] 赵钟祥[1] 冯育林[2] 曾陇梅[3] 祝晨蔯[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510006 [2]江西中医学院中药固体制剂制造技术国家工程研究中心,江西南昌330006 [3]中山大学化学与化学工程学院,广东广州510275

出　　处：《中山大学学报（自然科学版）》2009年第1期42-45,共4页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：国家中医药管理局重大科技专项资助项目(国中医药科2001ZDZX005);广东省中医药管理局基金资助项目(2007336);广州中医药大学创新基金资助项目(2007C016)

摘　　要：从岭南地区习用药毛冬青Ilexpubescens Hook.Et.Arn.根中分离得到2个三萜皂苷类化合物,经理化及波谱方法鉴定为ilexsaponin B1和ilexsaponin B2。首次利用2D NMR技术对此2个化合物的1H和13C NMR数据进行了全归属。药理活性研究表明,毛冬青总皂苷具有明显降低血浆粘度的作用。Two pentacyclic ursane triterpenoids, ilexsaponin B1 （1） and ilexsaponin B2 （2）, were isolated from the root of llex pubescens, a traditional Chinese medicine used for the treatment of cardiovascular diseases. They were elucidated by chemical, physical methods and spectroscopic analysis. The NMR spectra data of compounds were recorded and firstly completely assigned by 2D NMR experiments, including ^1H -^1H COSY, HSBC and HSQC. Ilex pubescens exhibited potent degrading Preliminary bioassays showed that the saponins from the root of the plasma viscosity in rats.

关 键 词：毛冬青Ilex pubescens Hook.Et.Arn. 三萜皂苷 NMR全归属 

分 类 号：O629.7[理学—有机化学]