水飞蓟宾的负离子电喷雾离子阱质谱研究  

Study on Silybin in Negative Mode by Ion Trap Mass Spectrometry

作　　者：韩建平[1] 李伟[1,2] 张超[1] 王宏志[1] 高钧[1] 刘昌孝[2,3] 

机构地区：[1]天津天士力集团有限公司,天津300402 [2]天津大学化工学院,天津300072 [3]天津药物研究院,天津药代动力学与药效动力学省部共建国家重点实验室,天津300193

出　　处：《质谱学报》2009年第1期6-11,共6页Journal of Chinese Mass Spectrometry Society

摘　　要：采用电喷雾离子阱(ESI-MS)质谱技术对水飞蓟宾的结构和裂解途径进行研究。采用ESI-MS获得了m/z481[M-H]-,采用ESI-MS2获得了m/z453、m/z301等碎片离子。发现ESI-MS2质谱生成A环和B环C—O—C键断裂的碎片,并对m/z453、m/z301特征碎片离子进行ESI-MS3质谱研究,归属了其主要特征碎片离子,分析和讨论了该化合物的结构和质谱特征。The structure and fragmentation pathway of silybin were elucidated by electron spray ionization mass spectrometry （ESI-MS）. Quasi-molecular ion peak m/z 481 [M-H]^- was detected by ESI-MS, and the ions of m/z 453 and rn/z 301 were detected by ESI-MS2. The fragment routes of characteristic were discussed on the basis of ESI mass spectra. The full scan MS2 spectra of silybin gave characteristic fragment ions formed through cleavage of the C--O--C bond at A-ring and B-ring. The full scan MS3 spectra of fragment m/z 453, m/z 301 was obtained by ion trap mass spectrometry. The characteristic fragmentation was used to prove the structure of m/z 453, m/z 301.

关 键 词：水飞蓟宾 电喷雾离子阱质谱 裂解途径 

分 类 号：O657.63[理学—分析化学]