肾病综合征患者血浆、尿中D-二聚体测定的临床研究  

THE LEVELS OF D - DIMER IN PLASMA AND URINE OF NEPHROTIC SYNDROME PATIENTS

作　　者：杨秋云[1] 张义国[1] 贾定武[1] 夏宝蔡[2] 王春 

机构地区：[1]河南医科大学附一院内三科,450052 [2]河南省电力医院 [3]河南省武陟县人民医院

出　　处：《中国现代医学杂志》1998年第4期17-18,共2页China Journal of Modern Medicine

摘　　要：采用双抗夹心ＥＬＩＳＡ，测定１９例肾病综合征（ＮＳ）患者和５０例正常人对照血交，尿中Ｄ－二聚体（ＤＤ）水平。同时检测末梢血小板计数（ＰＬＴ）和全血血小板最大聚集值（ＭＡ）。结果：ＮＳ组血浆，尿中ＤＤ分别为２．０８±０．８０ｍｇ／Ｌ，０．４０±０．１５ｍｇ／Ｌ均高于正常对照组，Ｐ〈０．０５；而ＰＬＴ为３１５．７±３８．５６×１０＾９／Ｌ及ＭＡ为１１．７±３．０ｏｈｍ，也显著高于正常对照组，Ｐ〈０．The levels of D — dimer in the plasma and urine of 19 nephrotic syndrome patients and 50 normal control subjects were assayed using a sandwich ELISA assay kit. Peripheral blood platelet counts and whole blood platelet maximum aggregation rates were also measured. The levels of D- dimer in the plasma and urine of the experimental group were 2. 08 ± 0. 80mg/L and 0.40 ± 0. 15mg/L and were significantly ? higher than the control group ( P < 0. 05). The platelet counts and maximum aggregation rates were 315. 7 ± 38. 56 X 109 /L and 11. 7 ± 3.0 ohm, and were also higher than the control group (P<0.01). These results indicate that nephrotic syndrome patients are in pro-coagulant and higher fibrolysis status.

关 键 词：肾病综合征 D-二聚体 血小板 尿液 测定 

分 类 号：R692[医药卫生—泌尿科学] R446.1[医药卫生—外科学]