药物中间体对氟苄胺的合成  

作　　者：姜华[1] 苏桂红[1] 

机构地区：[1]哈药集团制药总厂,黑龙江哈尔滨150086

出　　处：《黑龙江科技信息》2009年第8期179-179,67,共2页Heilongjiang Science and Technology Information

摘　　要：目的:合成药物中间体对氟苄胺。方法:以对硝基苯甲酸为原料经氟化、酰化、还原3步合成了药物中间体对氟苄胺。结果:总收率达30.43%。结论:本法具有原料易得、成本低廉、操作安全、工艺简单等特点。Objection：To synthesize ethyl p-Fluorobenzylamine.Methods：p-Fluorobenzylamine which was the intermediate compound of some medicine was synthesized by 3 steps fluorzation,acylation and reduction with p-Nitrobenzoic acid as starting material.Resuhs：The overall yield was 30.43%.Conclusion：This method was simple and safe.The raw material was abundant the cost was low.

关 键 词：对氟苄胺 对硝基苯甲酸 氟化 

分 类 号：TQ463.4[化学工程—制药化工] TQ463